List of Research
Central Institute(RIKEN CBS)
● : Principal Investigator ○ : Co-Investigator
Brain Mapping by Integrated Neurotechnologies for Disease Studies
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(A) Brain mapping and analysis of genetically-modified marmosets
●Hideyuki Okano（Marmoset Neural Architecture, RIKEN Center for Brain Science / School of Medicine, Keio University）
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(B) Generation and analysis of non-human primate models of Alzheimer’s disease
●Takaomi Saido（Proteolytic Neuroscience, RIKEN Center for Brain Science）
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(C) Tracer map of the marmoset brain
●Tetsuo Yamamori（Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science）
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(D) Generation of marmoset gene atlas
●Tomomi Shimogori（Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science）
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(E) Development of a high-performance, wide and contiguous field-of-view two-photon microscope
●Masanori Murayama（Haptic Perception and Cognitive Physiology, RIKEN Center for Brain Science）
○Masanori Matsuzaki（Brain Functional Dynamics Collaboration Laboratory, RIKEN Center for Brain Science）
○Tetsuo Yamamori（Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science）
○Misako Komatsu（Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science）
○Masanori Matsuzaki（Graduate School of Medicine, The University of Tokyo）
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(F)Structure, function, and molecular mechanism of the brain
●Atsushi Miyawaki（Cell Function Dynamics, RIKEN Center for Brain Science）
○Hiroyuki Kamiguchi（Neural Cell Dynamics, RIKEN Center for Brain Science）
○Motomasa Tanaka（Protein Conformation Diseases, RIKEN Center for Brain Science）
○Akiko Hayashi-Takagi（Multi-scale Biological Psychiatry, RIKEN Center for Brain Science）
○Hiroshi Tsugawa（Tokyo University of Agriculture and Technology）
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(G) Development of database, data analysis methods, and new MRI techniques
●Keiji Tanaka（Functional Magnetic Resonance Imaging, RIKEN Center for Brain Science）
○Alexander Woodward（Connectome Analysis, RIKEN Center for Brain Science）
○Henrik Skibbe（Brain Image Analysis, RIKEN Center for Brain Science）
○Taro Toyoizumi（Neural Computation and Adaptation, RIKEN Center for Brain Science）
○Fumiyasu Komaki（Mathematical Informatics Collaboration, RIKEN Center for Brain Science）
○Shin Ishii（Graduate School of Informatics, Kyoto University）
○Kenji Doya（Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University）
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(H) Development of animal resources for structural and functional analyses of primate brains
●Hiroyuki Kamiguchi （Deputy Director, RIKEN Center for Brain Science ）
○Yasuhiro Go（Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences）
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(I) Project management and promotion
●Shigeyoshi Itohara （Brain/MINDS office, RIKEN Center for Brain Science）
Marmoset Research
● : Principal Investigator ○ : Co-Investigator
Research on Neurodegenerative Disease Marmoset Models
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Study of developing neurodegenerative model marmosets and establishment of novel reproductive methodology
●Erika Sasaki（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Kenya Sato（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Wakako Kumita（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Takashi Inoue（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Yoko Kurotaki（Center of Basic Technology in Marmoset, Central Institute for Experimental Animals）
○Fumiko Seki（Live Imaging Center, Central Institute for Experimental Animals）
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Generation and evaluation of a marmoset model of dementia
●Kazuhiko Seki（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Eiko Minakawa （National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Ikuo Tomioka（Graduate School of Science and Technology, Shinshu University）
○Koichi Kato（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Yuko Saito（National Center Hospital, National Center of Neurology and Psychiatry）
○Toshihide Takeuchi （Life Science Research Institute, Kindai University）
Research on Wild Type Marmosets
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Common marmosets as experimental animals suitable for brain science research: research on breeding, housing, and distributing methods
●Keiji Wada（National Institute of Neuroscience, National Center of Neurology and Psychiatry ）
○Kazuhiko Seki（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Noritaka Ichinohe（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Tomomichi Oya （National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Ryoichi Saito（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
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Platform for marmoset research support
●Erika Sasaki（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Takashi Inoue（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Yoko Kurotaki（Center of Basic Technology in Marmoset, Central Institute for Experimental Animals）
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Establishment of a method for rearing marmosets of strong physique and providing marmosets
●Katsuki Nakamura（Center for the Evolutionary Origins of Human Behavior, Kyoto University）
Clinical Research
● : Principal Investigator ○ : Co-Investigator
Psychiatric disorders group
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Study for impairment of predictive function in psychiatric disorders using a bi-directional translational approach
●Shinsuke Koike（Graduate School of Arts and Sciences, The University of Tokyo ）
○Toshiaki Onitsuka（Graduate School of Medical Sciences, Kyushu University ）
○Misako Komatsu（RIKEN Center for Brain Science ）
○Kenichiro Miura（National Institute of Mental Health, National Center of Neurology and Psychiatry ）
○Kenji Tanaka（School of Medicine, Keio University）
○Masatoshi Yoshida（Center for Human Nature, Artificial Intelligence, and Neuroscience, Hokkaido University）
○Masanori Matsuzaki（Graduate School of Medicine, The University of Tokyo）
○Takanori Uka（Graduate Faculty of Interdisciplinary Research, University of Yamanashi）
○Sho Yagishita（Graduate School of Medicine, The University of Tokyo）
○Maeri Yamamoto（Nagoya University Hospital, Nagoya University）
○Kiyoto Kasai（Graduate School of Medicine, The University of Tokyo ）
○Naoto Kunii（University Hospital, The University of Tokyo ）
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Studies on psychiatric disorders using mutant marmosets generated by autologous embryo transfer
●Atsu Aiba（Graduate School of Medicine, The University of Tokyo ）
○Masanobu Kano（Graduate School of Medicine, The University of Tokyo ）
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Identification and functional analysis of neural circuit responsible for mental disorders based on genomic information of brain
●Kazuya Iwamoto（Faculty of Life Sciences, Kumamoto University）
○Yasuto Kunii（International Research Institute of Disaster Science, Tohoku University）
○Tadafumi Kato（Graduate School of Medicine, Juntendo University）
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Studies on neural circuit and molecular pathology based on human genome mutations in psychiatric disorders
●Kozo Kaibuchi（International Center for Brain Science, Fujita Health University ）
○Norio Ozaki（Graduate School of Medicine, Nagoya University ）
○Yukihiro Noda（Faculty of Pharmacy, Meijo University）
Neurodegenerative diseases group
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Translational research for neural circuitry pathologies and biomarkers for prodromal and clinical Parkinson’s disease
●Ryosuke Takahashi（Graduate School of Medicine, Kyoto University）
○Yuji Takahashi（NCNP Hospital, National Center of Neurology and Psychiatry ）
○Haruhiko Kishima（Graduate School of Medicine, Osaka University）
○Takashi Hanakawa（Graduate School of Medicine, Kyoto University / Integrative Brain Imaging Center, National Center of Neurology and Psychiatry ）
○Nobutaka Hattori（Graduate School of Medicine, Juntendo University）
○Hideki Mochizuki （Faculty of Medicine, Osaka University）
○Dai Watanabe（Graduate School of Medicine, Kyoto university）
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Molecular imaging study of pathological protein aggregation and transmission and neural circuit disruptions
●Makoto Higuchi（Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology）
○Masato Hasegawa（Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science）
○Takuya Takahashi（Graduate School of Medicine, Yokohama City University）
○Taisuke Tomita（Graduate School of Pharmaceutical Sciences, The University of Tokyo ）
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Understanding the mechanism of Aβ-induced aggregated tau propagation and neurocircuit degeneration in Alzheimer's disease
●Taisuke Tomita（Graduate School of Pharmaceutical Sciences, The University of Tokyo ）
○Takeshi Ikeuchi（Brain Research Institute, Niigata University）
○Tadafumi Hashimoto（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Kaoru Yamada（Graduate School of Medicine, The University of Tokyo ）
○Yukiko Hori（Graduate School of Pharmaceutical Sciences, The University of Tokyo ）
○Sho Takatori（Graduate School of Pharmaceutical Sciences, The University of Tokyo）
Technology Development
● : Principal Investigator ○ : Co-Investigator
FY2019～
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Acoustic-optical technologies for investigating deep brain area
●Keiichi Nakagawa（Graduate School of Engineering, The University of Tokyo）
○Shu Takagi（School of Engineering, The University of Tokyo）
○Eiji Okada（Faculty of Science and Technology, Keio University）
○Hiroshi Fukuoka（Department of Mechanical Engineering, National Institute Of Technology, Nara College ）
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Development in gene transfer techniques for primate brains by means of novel viral vector systems
●Masahiko Takada（Center for the Evolutionary Origins of Human Behavior, Kyoto University）
○Kazuhiko Seki（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Katsuki Nakamura（Center for the Evolutionary Origins of Human Behavior, Kyoto University）
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Research on high-speed super-resolution in vivo 3D imaging method by utilizing advanced laser light technology
●Tomomi Nemoto（Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences）
○Shunichi Sato（Institute of Multidisciplinary Research for Advanced Materials, Tohoku University ）
○Hiroyuki Yokoyama（New Industry Creation Hatchery Center, Tohoku University）
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Elucidating circuit function via multiplexed activity trace labeling and all-optical interrogation
●Haruhiko Bito（Graduate School of Medicine, The University of Tokyo ）
○Masaki Kakeyama（Faculty of Human Sciences, Waseda University ）
○Satoshi Manita（Graduate Faculty of Interdisciplinary Research, University of Yamanashi ）
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Multiple scale functional mapping of neuronal dynamics
●Kazuo Kitamura （Graduate Faculty of Interdisciplinary Research, University of Yamanashi）
○Yuichiro Ishii（Graduate School of Medicine, The University of Tokyo）
○Hiroyuki Okuno（Graduate School of Medical and Dental Sciences, Kagoshima University ）
○Takayasu Mikuni（Brain Research Institute, Niigata University）
○Keisuke Ota（Graduate School of Medicine, The University of Tokyo）
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Development of innovative photo-activated molecules to induce de novo synaptic plasticity in vitro and in vivo
●Ayako M. Watabe（Institute of Clinical Medicine and Research, The Jikei University）
○Manabu Abe（Brain Research Institute, Niigata University）
○Shun Hamada（Graduate Faculty of Interdisciplinary Research, University of Yamanashi）
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Study of correlative microscopy on neuronal circuits and ultrastructure
●Yusuke Hirabayashi（Graduate School of Engineering, The University of Tokyo）
○Hisato Maruoka（Graduate School of Medicine, The University of Tokyo）
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Efficiency improvement and standardization of cortical microcircuit analysis using 3D reconstruction of large volume EM data set
●Yoshiyuki Kubota（National Institute for Physiological Science, National Institutes of Natural Sciences）
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Wide-field and high-resolution functional mapping of marmoset motor cortex
●Teppei Ebina（Graduate School of Medicine, The University of Tokyo）
○Masanori Matsuzaki（Graduate School of Medicine, The University of Tokyo）
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Development of a method for linear modeling of brain-state and stimulus-related information
●Junichi Chikazoe（Neurotechnology R&D Unit, Araya Inc.）
○Masakazu Agetsuma（National Institute for Physiological Science, National Institutes of Natural Sciences）
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Development of innovative nanosheets for pushing the limits of deep brain imaging
●Yosuke Okamura（Department of Applied Chemistry, Tokai University）
○Yutaro Kashiwagi（Graduate School of Medicine, The University of Tokyo）
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Development of data-driven integrate model using Brain/MINDS database
●Ken Nakae（Graduate School of Informatics, Kyoto Univeristy）
○Hiromichi Tsukada（Center for Mathematical Science and Artificial Intelligence, Chubu University）
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Advanced Multi-Linc analysis to clarify circuit mechanisms of cortical and subcortical functions
●Yoshikazu Isomura（Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University）
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Development of novel optogenetic neural circuit manipulation methods by wireless power transfer system
●Itaru Imayoshi（Graduate School of Biostudies, Kyoto University）
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Development of an innovative embryo manipulating system for the generation of genetically modified marmosets
●Toshikuni Sasaoka（Brain Research Institute, Niigata University）
○Kenji Sakimura（Brain Research Institute, Niigata University）
○Manabu Abe（Brain Research Institute, Niigata University）
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Structural and functional mapping of brain regions controlling eye movements and cognitive functions in marmosets
●Hirotaka Onoe（Graduate School of Medicine, Kyoto Univeristy）
○Masatoshi Kasai（Graduate School of Medicine, Kyoto Univeristy）
○Tadashi Isa（Graduate School of Medicine, Kyoto Univeristy）
FY2021～
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Development and provision of adeno-associated virus vectors optimized for marmoset brain research
●Hirokazu Hirai（Graduate School of Medicine, Gunma University）
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Establishment of “Anterograde CLEM” that links multi-scale structural information using virus vectors
●Hiroyuki Hioki（Graduate School of Medicine, Juntendo University）
○Takahiro Furuta（Graduate School of Dentistry, Osaka University ）
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Development of a viral vector system improved for pathway-specific labeling and manipulation: application for cortico-basal ganglia network analysis in common marmosets
●Kazuto Kobayashi（School of Medicine, Fukushima Medical University）
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Multi-scale functional mapping of the marmoset brain and development of ultra-wide and ultra-deep functional mapping techniques
●Kenichi Ohki（Graduate School of Medicine, The University of Tokyo ）
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Establishment of somatic cell nuclear transfer (SCNT) technology in common marmosets
●Shogo Matoba（RIKEN BioResource Research Center ）
○Yoko Kurotaki（Center of Basic Technology in Marmoset, Central Institute for Experimental Animals ）
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Studies on the function and dysfunction of the prefrontal cortex and deep brain structures of marmosets
●Atsushi Nambu（National Institute for Physiological Sciences, National Institutes of Natural Sciences ）
○Makoto Osanai（Graduate School of Medicine, Osaka University ）
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Development of a highly scalable imaging system optimized for the primate brain
●Hitoshi Hashimoto（Graduate School of Pharmaceutical Sciences, Osaka University ）
○Atsushi Kasai（Graduate School of Pharmaceutical Sciences, Osaka University ）
○Kaoru Seiriki（Graduate School of Pharmaceutical Sciences, Osaka University ）
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Development of novel translational test batteries using FTLD model marmosets
●Shinsuke Ishigaki（Molecular Neuroscience Research Center, Shiga University of Medical Science ）
○Junichi Hata（The Jikei University School of Medicine ）
○Katsuki Nakamura（Center for the Evolutionary Origins of Human Behavior, Kyoto University ）
