List of Research
Central Institute(RIKEN CBS)
● : Principal Investigator ○ : Co-Investigator
Brain Mapping by Integrated Neurotechnologies for Disease Studies
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(A) Brain mapping and analysis of genetically-modified marmosets
●Hideyuki Okano（Marmoset Neural Architecture, RIKEN Center for Brain Science / School of Medicine, Keio University）
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(B) Generation and analysis of non-human primate models of Alzheimer’s disease
●Takaomi Saido（Proteolytic Neuroscience, RIKEN Center for Brain Science）
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(C) Tracer map of the marmoset brain
●Tetsuo Yamamori（Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science）
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(D) Generation of marmoset gene atlas
●Tomomi Shimogori（Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science）
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(E) Development of a high-performance, wide and contiguous field-of-view two-photon microscope
●Masanori Murayama（Haptic Perception and Cognitive Physiology, RIKEN Center for Brain Science）
○Masanori Matsuzaki（Brain Functional Dynamics Collaboration Laboratory, RIKEN Center for Brain Science）
○Tetsuo Yamamori（Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science）
○Misako Komatsu（Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science）
○Masanori Matsuzaki（Graduate School of Medicine, The University of Tokyo）
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(F)Structure, function, and molecular mechanism of the brain
●Atsushi Miyawaki（Cell Function Dynamics, RIKEN Center for Brain Science）
○Hiroyuki Kamiguchi（Neural Cell Dynamics, RIKEN Center for Brain Science）
○Motomasa Tanaka（Protein Conformation Diseases, RIKEN Center for Brain Science）
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(G) Development of database, data analysis methods, and new MRI techniques
●Keiji Tanaka（Cognitive Brain Mapping, RIKEN Center for Brain Science）
○Alexander Woodward（Connectome Analysis, RIKEN Center for Brain Science）
○Henrik Skibbe（Brain Image Analysis, RIKEN Center for Brain Science）
○Taro Toyoizumi（Neural Computation and Adaptation, RIKEN Center for Brain Science）
○Fumiyasu Komaki（Mathematical Informatics Collaboration, RIKEN Center for Brain Science）
○Shin Ishii（Graduate School of Informatics, Kyoto University）
○Kenji Doya（Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University）
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(H) Development of animal resources for structural and functional analyses of primate brains
●Hiroyuki Kamiguchi （Acting Director, RIKEN Center for Brain Science ）
○Yasuhiro Go（Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences）
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(I) Project management and promotion
●Shigeyoshi Itohara （Brain/MINDS office, RIKEN Center for Brain Science）
Marmoset Research
● : Principal Investigator ○ : Co-Investigator
Research on Neurodegenerative Disease Marmoset Models
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Study of developing neurodegenerative model marmosets and establishment of novel reproductive methodology
●Erika Sasaki（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Kenya Sato（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Wakako Kumita（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Takashi Inoue（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Yoko Kurotaki（Center of Basic Technology in Marmoset, Central Institute for Experimental Animals）
○Fumiko Seki（Live Imaging Center, Central Institute for Experimental Animals）
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Generation and evaluation of a marmoset model of dementia
●Kazuhiko Seki（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Eiko Minakawa （National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Ikuo Tomioka（Graduate School of Science and Technology, Shinshu University）
○Koichi Kato（Integrative Brain Imaging Center, National Center of Neurology and Psychiatry）
○Yuko Saito（National Center Hospital, National Center of Neurology and Psychiatry）
○Toshihide Takeuchi （Graduate School of Medicine, Osaka University）
Research on Wild Type Marmosets
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Common marmosets as experimental animals suitable for brain science research: research on breeding, housing, and distributing methods
●Keiji Wada（National Institute of Neuroscience, National Center of Neurology and Psychiatry ）
○Kazuhiko Seki（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Noritaka Ichinohe（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Tomomichi Oya （National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Ryoichi Saito（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
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Platform for marmoset research support
●Erika Sasaki（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Takashi Inoue（Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals）
○Yoko Kurotaki（Center of Basic Technology in Marmoset, Central Institute for Experimental Animals）
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Establishment of a method for rearing marmosets of strong physique and providing marmosets
●Katsuki Nakamura（Primate Research Institute, Kyoto University）
Clinical Research
● : Principal Investigator ○ : Co-Investigator
Psychiatric disorders group
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Study for impairment of predictive function in psychiatric disorders using a bi-directional translational approach
●Shinsuke Koike（Graduate School of Arts and Sciences, The University of Tokyo ）
○Toshiaki Onitsuka（Graduate School of Medical Sciences, Kyushu University ）
○Misako Komatsu（RIKEN Center for Brain Science ）
○Kenichiro Miura（National Institute of Mental Health, National Center of Neurology and Psychiatry ）
○Kenji Tanaka（School of Medicine, Keio University）
○Masatoshi Yoshida（Center for Human Nature, Artificial Intelligence, and Neuroscience, Hokkaido University）
○Masanori Matsuzaki（Graduate School of Medicine, The University of Tokyo）
○Takanori Uka（Graduate Faculty of Interdisciplinary Research, University of Yamanashi）
○Sho Yagishita（Graduate School of Medicine, The University of Tokyo）
○Maeri Yamamoto（Nagoya University Hospital, Nagoya University）
○Kiyoto Kasai（Graduate School of Medicine, The University of Tokyo ）
○Naoto Kunii（University Hospital, The University of Tokyo ）
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Studies on psychiatric disorders using mutant marmosets generated by autologous embryo transfer
●Atsu Aiba（Graduate School of Medicine, The University of Tokyo ）
○Masanobu Kano（Graduate School of Medicine, The University of Tokyo ）
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Identification and functional analysis of neural circuit responsible for mental disorders based on genomic information of brain
●Kazuya Iwamoto（Faculty of Life Sciences, Kumamoto University）
○Yasuto Kunii（International Research Institute of Disaster Science, Tohoku University）
○Tadafumi Kato（Graduate School of Medicine, Juntendo University）
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Studies on neural circuit and molecular pathology based on human genome mutations in psychiatric disorders
●Kozo Kaibuchi（Graduate School of Medicine, Nagoya University ）
○Norio Ozaki（Graduate School of Medicine, Nagoya University ）
○Yukihiro Noda（Faculty of Pharmacy, Meijo University）
○Shinsuke Ishigaki（Graduate School of Medicine, Nagoya University ）
Neurodegenerative diseases group
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Translational research for neural circuitry pathologies and biomarkers for prodromal and clinical Parkinson’s disease
●Ryosuke Takahashi（Graduate School of Medicine, Kyoto University）
○Yuji Takahashi（NCNP Hospital, National Center of Neurology and Psychiatry ）
○Haruhiko Kishima（Graduate School of Medicine, Osaka University）
○Takashi Hanakawa（Integrative Brain Imaging Center, National Center of Neurology and Psychiatry ）
○Nobutaka Hattori（Graduate School of Medicine, Juntendo University）
○Hideki Mochizuki （Faculty of Medicine, Osaka University）
○Dai Watanabe（Graduate School of Medicine, Kyoto university）
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Molecular imaging study of pathological protein aggregation and transmission and neural circuit disruptions
●Makoto Higuchi（Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology）
○Masato Hasegawa（Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science）
○Takuya Takahashi（Graduate School of Medicine, Yokohama City University）
○Taisuke Tomita（Graduate School of Pharmaceutical Sciences, The University of Tokyo ）
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Understanding the mechanism of Aβ-induced aggregated tau propagation and neurocircuit degeneration in Alzheimer’s disease
●Taisuke Tomita（Graduate School of Pharmaceutical Sciences, The University of Tokyo ）
○Takeshi Ikeuchi（Brain Research Institute, Niigata University）
○Tadafumi Hashimoto（Graduate School of Medicine, The University of Tokyo ）
○Kaoru Yamada（Graduate School of Medicine, The University of Tokyo ）
○Yukiko Hori（Graduate School of Pharmaceutical Sciences, The University of Tokyo ）
○Sho Takatori（Graduate School of Pharmaceutical Sciences, The University of Tokyo）
Technology Development
● : Principal Investigator ○ : Co-Investigator
FY2017～
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Multimodal multi-scale functional mapping of marmoset brain and development of functional mapping at ultra-fine scale
●Kenichi Ohki（Graduate School of Medicine, The University of Tokyo）
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Analyze structures and functions of marmoset brains by multi-scale and multi-modal approaches
●Atsushi Nambu（National Institute for Physiological Sciences, National Institutes of Natural Sciences）
○Hajime Mushiake（School of Medicine , Tohoku University）
○Makoto Osanai（Graduate School of Medicine, Osaka University）
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AAV vector-mediated cell type-specific gene knock-down / knock-out in marmoset CNS in vivo
●Hirokazu Hirai（Graduate School of Medicine, Gunma University）
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Mapping the structure and function of the cortico-basal ganglia network in marmosets by use of pathway-specific labeling and manipulation technology
●Kazuto Kobayashi（School of Medicine, Fukushima Medical University）
○Miwako Yamasaki（Faculty of Medicine, Hokkaido University）
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Production of knockout marmoset using spermatogenic cells
●Takashi Shinohara（Graduate School of Medicine, Kyoto University）
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Zoom-in to the ultrastructure level from the whole brain level using a tissue-clearing method as the cornerstone
●Hiroyuki Hioki（School of Medicine, Juntendo University）
○ Takahiro Furuta（Graduate School of Dentistry, Osaka University）
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Development of neural circuit tracing for mapping the connectome in the common marmoset
●Fumitaka Osakada（Graduate School of Pharmaceutical Sciences, Nagoya University）
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Development of innovative method for an all-optical electrophysiology to measure and manipulate neural activity
●Masayuki Sakamoto（Graduate School of Biostudies, Kyoto University）
○Yuki Sudo（Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University）
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Development of innovative wide-view mapping of synaptic ensemble in the psychiatric model
●Akiko Hayashi-Takagi（RIKEN Center for Brain Science）
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Development of 3D imaging and analysis pipeline for marmoset brain
●Hiroki Ueda（Graduate School of Medicine, The University of Tokyo）
○Rikuhiro Yamada（RIKEN Center for Biosystems Dynamics Research）
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Super-multicolor labeling for automatic reconstruction of neuronal circuits
●Takeshi Imai（Graduate School of Medical Sciences, Kyushu University）
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Development of a method for high speed and high resolution whole-brain imaging in primates
●Hitoshi Hashimoto（Graduate School of Pharmaceutical Sciences, Osaka University）
FY2019～
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Acoustic-optical technologies for investigating deep brain area
●Keiichi Nakagawa（Graduate School of Engineering, The University of Tokyo）
○Shu Takagi（School of Engineering, The University of Tokyo）
○Eiji Okada（Faculty of Science and Technology, Keio University）
○Hiroshi Fukuoka（Department of Mechanical Engineering, National Institute Of Technology, Nara College ）
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Development in gene transfer techniques for primate brains by means of novel viral vector systems
●Masahiko Takada（Primate Research Institute, Kyoto University）
○Kazuhiko Seki（National Institute of Neuroscience, National Center of Neurology and Psychiatry）
○Katsuki Nakamura（Primate Research Institute, Kyoto University）
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Research on high-speed super-resolution in vivo 3D imaging method by utilizing advanced laser light technology
●Tomomi Nemoto（Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences）
○Shunichi Sato（Institute of Multidisciplinary Research for Advanced Materials, Tohoku University ）
○Hiroyuki Yokoyama（New Industry Creation Hatchery Center, Tohoku University）
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Elucidating circuit function via multiplexed activity trace labeling and all-optical interrogation
●Haruhiko Bito（Graduate School of Medicine, The University of Tokyo ）
○Masaki Kakeyama（Faculty of Human Sciences, Waseda University ）
○Satoshi Manita（Graduate Faculty of Interdisciplinary Research, University of Yamanashi ）
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Wide-field and high-resolution functional mapping of marmoset motor cortex
●Teppei Ebina（Graduate School of Medicine, The University of Tokyo）
○Masanori Matsuzaki（Graduate School of Medicine, The University of Tokyo）
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Multiple scale functional mapping of neuronal dynamics
●Kazuo Kitamura （Graduate Faculty of Interdisciplinary Research, University of Yamanashi）
○Yuichiro Ishii（Graduate School of Medicine, The University of Tokyo）
○Hiroyuki Okuno（Graduate School of Medical and Dental Sciences, Kagoshima University ）
○Takayasu Mikuni（Brain Research Institute, Niigata University）
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Development of innovative photo-activated molecules to induce de novo synaptic plasticity in vitro and in vivo
●Ayako M. Watabe（Institute of Clinical Medicine and Research, The Jikei University）
○Manabu Abe（Brain Research Institute, Niigata University）
○Shun Hamada（Graduate Faculty of Interdisciplinary Research, University of Yamanashi）
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Study of correlative microscopy on neuronal circuits and ultrastructure
●Yusuke Hirabayashi（Graduate School of Engineering, The University of Tokyo）
○Hisato Maruoka（Graduate School of Medicine, The University of Tokyo）
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Development of data-driven integrate model using Brain/MINDS database
●Ken Nakae（Graduate School of Informatics, Kyoto Univeristy）
○Hiromichi Tsukada（Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University）
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Establishment of high efficiency method for long transgene introduction based on common marmoset
●Ikuo Tomioka（Graduate School of Science and Technology, Shinshu University ）
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Advanced Multi-Linc analysis to clarify circuit mechanisms of cortical and subcortical functions
●Yoshikazu Isomura（Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University）
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Efficiency improvement and standardization of cortical microcircuit analysis using 3D reconstruction of large volume EM data set
●Yoshiyuki Kubota（National Institute for Physiological Science, National Institutes of Natural Sciences）
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Development of novel optogenetic neural circuit manipulation methods by wireless power transfer system
●Itaru Imayoshi（Graduate School of Biostudies, Kyoto University）
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Development of an innovative embryo manipulating system for the generation of genetically modified marmosets
●Toshikuni Sasaoka（Brain Research Institute, Niigata University）
○Kenji Sakimura（Brain Research Institute, Niigata University）
○Ena Nakatsukasa（Brain Research Institute, Niigata University）
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Development of a method for linear modeling of brain-state and stimulus-related information
●Junichi Chikazoe（National Institute for Physiological Science, National Institutes of Natural Sciences）
○Masakazu Agetsuma（National Institute for Physiological Science, National Institutes of Natural Sciences）
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Development of innovative nanosheets for pushing the limits of deep brain imaging
●Yosuke Okamura（Department of Applied Chemistry, Tokai University）
○Yutaro Kashiwagi（Graduate School of Medicine, The University of Tokyo）
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Structural and functional mapping of brain regions controlling eye movements and cognitive functions in marmosets
●Hirotaka Onoe（Graduate School of Medicine, Kyoto Univeristy）
○Masatoshi Kasai（Graduate School of Medicine, Kyoto Univeristy）
○Tadashi Isa（Graduate School of Medicine, Kyoto Univeristy）
