List of Research
Central Institute(RIKEN CBS)
● : Principal Investigator ○ : Co-Investigator
Brain Mapping by Integrated Neurotechnologies for Disease Studies
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(A) Brain mapping and analysis of genetically-modified marmosets
●Hideyuki Okano(Marmoset Neural Architecture, RIKEN Center for Brain Science / School of Medicine, Keio University)
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(B) Generation and analysis of non-human primate models of Alzheimer’s disease
●Takaomi Saido(Proteolytic Neuroscience, RIKEN Center for Brain Science)
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(C) Tracer map of the marmoset brain
●Tetsuo Yamamori(Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science)
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(D) Generation of marmoset gene atlas
●Tomomi Shimogori(Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science)
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(E) Development of a high-performance, wide and contiguous field-of-view two-photon microscope
●Masanori Murayama(Haptic Perception and Cognitive Physiology, RIKEN Center for Brain Science)
○Masanori Matsuzaki(Brain Functional Dynamics Collaboration Laboratory, RIKEN Center for Brain Science)
○Tetsuo Yamamori(Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science)
○Misako Komatsu(Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science)
○Masanori Matsuzaki(Graduate School of Medicine, The University of Tokyo)
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(F)Structure, function, and molecular mechanism of the brain
●Atsushi Miyawaki(Cell Function Dynamics, RIKEN Center for Brain Science)
○Hiroyuki Kamiguchi(Neural Cell Dynamics, RIKEN Center for Brain Science)
○Motomasa Tanaka(Protein Conformation Diseases, RIKEN Center for Brain Science)
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(G) Development of database, data analysis methods, and new MRI techniques
●Keiji Tanaka(Cognitive Brain Mapping, RIKEN Center for Brain Science)
○Alexander Woodward(Connectome Analysis, RIKEN Center for Brain Science)
○Henrik Skibbe(Brain Image Analysis, RIKEN Center for Brain Science)
○Taro Toyoizumi(Neural Computation and Adaptation, RIKEN Center for Brain Science)
○Fumiyasu Komaki(Mathematical Informatics Collaboration, RIKEN Center for Brain Science)
○Shin Ishii(Graduate School of Informatics, Kyoto University)
○Kenji Doya(Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University)
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(H) Development of animal resources for structural and functional analyses of primate brains
●Hiroyuki Kamiguchi (Acting Director, RIKEN Center for Brain Science )
○Yasuhiro Go(Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences)
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(I) Project management and promotion
●Shigeyoshi Itohara (Brain/MINDS office, RIKEN Center for Brain Science)
Marmoset Research
● : Principal Investigator ○ : Co-Investigator
Research on Neurodegenerative Disease Marmoset Models
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Study of developing neurodegenerative model marmosets and establishment of novel reproductive methodology
●Erika Sasaki(Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals)
○Kenya Sato(Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals)
○Wakako Kumita(Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals)
○Takashi Inoue(Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals)
○Yoko Kurotaki(Center of Basic Technology in Marmoset, Central Institute for Experimental Animals)
○Fumiko Seki(Live Imaging Center, Central Institute for Experimental Animals)
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Generation and evaluation of a marmoset model of dementia
●Kazuhiko Seki(National Institute of Neuroscience, National Center of Neurology and Psychiatry)
○Eiko Minakawa (National Institute of Neuroscience, National Center of Neurology and Psychiatry)
○Ikuo Tomioka(Graduate School of Science and Technology, Shinshu University)
○Koichi Kato(Integrative Brain Imaging Center, National Center of Neurology and Psychiatry)
○Yuko Saito(National Center Hospital, National Center of Neurology and Psychiatry)
○Toshihide Takeuchi (Graduate School of Medicine, Osaka University)
Research on Wild Type Marmosets
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Common marmosets as experimental animals suitable for brain science research: research on breeding, housing, and distributing methods
●Keiji Wada(National Institute of Neuroscience, National Center of Neurology and Psychiatry )
○Kazuhiko Seki(National Institute of Neuroscience, National Center of Neurology and Psychiatry)
○Noritaka Ichinohe(National Institute of Neuroscience, National Center of Neurology and Psychiatry)
○Tomomichi Oya (National Institute of Neuroscience, National Center of Neurology and Psychiatry)
○Ryoichi Saito(National Institute of Neuroscience, National Center of Neurology and Psychiatry)
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Platform for marmoset research support
●Erika Sasaki(Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals)
○Takashi Inoue(Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals)
○Yoko Kurotaki(Center of Basic Technology in Marmoset, Central Institute for Experimental Animals)
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Establishment of a method for rearing marmosets of strong physique and providing marmosets
●Katsuki Nakamura(Primate Research Institute, Kyoto University)
Clinical Research
● : Principal Investigator ○ : Co-Investigator
Psychiatric disorders group
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Study for impairment of predictive function in psychiatric disorders using a bi-directional translational approach
●Shinsuke Koike(Graduate School of Arts and Sciences, The University of Tokyo )
○Toshiaki Onitsuka(Graduate School of Medical Sciences, Kyushu University )
○Misako Komatsu(RIKEN Center for Brain Science )
○Kenichiro Miura(National Institute of Mental Health, National Center of Neurology and Psychiatry )
○Kenji Tanaka(School of Medicine, Keio University)
○Masatoshi Yoshida(Center for Human Nature, Artificial Intelligence, and Neuroscience, Hokkaido University)
○Masanori Matsuzaki(Graduate School of Medicine, The University of Tokyo)
○Takanori Uka(Graduate Faculty of Interdisciplinary Research, University of Yamanashi)
○Sho Yagishita(Graduate School of Medicine, The University of Tokyo)
○Maeri Yamamoto(Nagoya University Hospital, Nagoya University)
○Kiyoto Kasai(Graduate School of Medicine, The University of Tokyo )
○Naoto Kunii(University Hospital, The University of Tokyo )
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Studies on psychiatric disorders using mutant marmosets generated by autologous embryo transfer
●Atsu Aiba(Graduate School of Medicine, The University of Tokyo )
○Masanobu Kano(Graduate School of Medicine, The University of Tokyo )
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Identification and functional analysis of neural circuit responsible for mental disorders based on genomic information of brain
●Kazuya Iwamoto(Faculty of Life Sciences, Kumamoto University)
○Yasuto Kunii(International Research Institute of Disaster Science, Tohoku University)
○Tadafumi Kato(Graduate School of Medicine, Juntendo University)
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Studies on neural circuit and molecular pathology based on human genome mutations in psychiatric disorders
●Kozo Kaibuchi(Graduate School of Medicine, Nagoya University )
○Norio Ozaki(Graduate School of Medicine, Nagoya University )
○Yukihiro Noda(Faculty of Pharmacy, Meijo University)
○Shinsuke Ishigaki(Graduate School of Medicine, Nagoya University )
Neurodegenerative diseases group
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Translational research for neural circuitry pathologies and biomarkers for prodromal and clinical Parkinson’s disease
●Ryosuke Takahashi(Graduate School of Medicine, Kyoto University)
○Yuji Takahashi(NCNP Hospital, National Center of Neurology and Psychiatry )
○Haruhiko Kishima(Graduate School of Medicine, Osaka University)
○Takashi Hanakawa(Integrative Brain Imaging Center, National Center of Neurology and Psychiatry )
○Nobutaka Hattori(Graduate School of Medicine, Juntendo University)
○Hideki Mochizuki (Faculty of Medicine, Osaka University)
○Dai Watanabe(Graduate School of Medicine, Kyoto university)
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Molecular imaging study of pathological protein aggregation and transmission and neural circuit disruptions
●Makoto Higuchi(Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology)
○Masato Hasegawa(Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science)
○Takuya Takahashi(Graduate School of Medicine, Yokohama City University)
○Taisuke Tomita(Graduate School of Pharmaceutical Sciences, The University of Tokyo )
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Understanding the mechanism of Aβ-induced aggregated tau propagation and neurocircuit degeneration in Alzheimer's disease
●Taisuke Tomita(Graduate School of Pharmaceutical Sciences, The University of Tokyo )
○Takeshi Ikeuchi(Brain Research Institute, Niigata University)
○Tadafumi Hashimoto(Graduate School of Medicine, The University of Tokyo )
○Kaoru Yamada(Graduate School of Medicine, The University of Tokyo )
○Yukiko Hori(Graduate School of Pharmaceutical Sciences, The University of Tokyo )
○Sho Takatori(Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Technology Development
● : Principal Investigator ○ : Co-Investigator
FY2017~
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Multimodal multi-scale functional mapping of marmoset brain and development of functional mapping at ultra-fine scale
●Kenichi Ohki(Graduate School of Medicine, The University of Tokyo)
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Analyze structures and functions of marmoset brains by multi-scale and multi-modal approaches
●Atsushi Nambu(National Institute for Physiological Sciences, National Institutes of Natural Sciences)
○Hajime Mushiake(School of Medicine , Tohoku University)
○Makoto Osanai(Graduate School of Medicine, Osaka University)
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AAV vector-mediated cell type-specific gene knock-down / knock-out in marmoset CNS in vivo
●Hirokazu Hirai(Graduate School of Medicine, Gunma University)
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Mapping the structure and function of the cortico-basal ganglia network in marmosets by use of pathway-specific labeling and manipulation technology
●Kazuto Kobayashi(School of Medicine, Fukushima Medical University)
○Miwako Yamasaki(Faculty of Medicine, Hokkaido University)
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Production of knockout marmoset using spermatogenic cells
●Takashi Shinohara(Graduate School of Medicine, Kyoto University)
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Zoom-in to the ultrastructure level from the whole brain level using a tissue-clearing method as the cornerstone
●Hiroyuki Hioki(School of Medicine, Juntendo University)
○ Takahiro Furuta(Graduate School of Dentistry, Osaka University)
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Development of neural circuit tracing for mapping the connectome in the common marmoset
●Fumitaka Osakada(Graduate School of Pharmaceutical Sciences, Nagoya University)
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Development of innovative method for an all-optical electrophysiology to measure and manipulate neural activity
●Masayuki Sakamoto(Graduate School of Biostudies, Kyoto University)
○Yuki Sudo(Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)
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Development of innovative wide-view mapping of synaptic ensemble in the psychiatric model
●Akiko Hayashi-Takagi(RIKEN Center for Brain Science)
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Development of 3D imaging and analysis pipeline for marmoset brain
●Hiroki Ueda(Graduate School of Medicine, The University of Tokyo)
○Rikuhiro Yamada(RIKEN Center for Biosystems Dynamics Research)
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Super-multicolor labeling for automatic reconstruction of neuronal circuits
●Takeshi Imai(Graduate School of Medical Sciences, Kyushu University)
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Development of a method for high speed and high resolution whole-brain imaging in primates
●Hitoshi Hashimoto(Graduate School of Pharmaceutical Sciences, Osaka University)
FY2019~
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Acoustic-optical technologies for investigating deep brain area
●Keiichi Nakagawa(Graduate School of Engineering, The University of Tokyo)
○Shu Takagi(School of Engineering, The University of Tokyo)
○Eiji Okada(Faculty of Science and Technology, Keio University)
○Hiroshi Fukuoka(Department of Mechanical Engineering, National Institute Of Technology, Nara College )
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Development in gene transfer techniques for primate brains by means of novel viral vector systems
●Masahiko Takada(Primate Research Institute, Kyoto University)
○Kazuhiko Seki(National Institute of Neuroscience, National Center of Neurology and Psychiatry)
○Katsuki Nakamura(Primate Research Institute, Kyoto University)
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Research on high-speed super-resolution in vivo 3D imaging method by utilizing advanced laser light technology
●Tomomi Nemoto(Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences)
○Shunichi Sato(Institute of Multidisciplinary Research for Advanced Materials, Tohoku University )
○Hiroyuki Yokoyama(New Industry Creation Hatchery Center, Tohoku University)
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Elucidating circuit function via multiplexed activity trace labeling and all-optical interrogation
●Haruhiko Bito(Graduate School of Medicine, The University of Tokyo )
○Masaki Kakeyama(Faculty of Human Sciences, Waseda University )
○Satoshi Manita(Graduate Faculty of Interdisciplinary Research, University of Yamanashi )
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Wide-field and high-resolution functional mapping of marmoset motor cortex
●Teppei Ebina(Graduate School of Medicine, The University of Tokyo)
○Masanori Matsuzaki(Graduate School of Medicine, The University of Tokyo)
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Multiple scale functional mapping of neuronal dynamics
●Kazuo Kitamura (Graduate Faculty of Interdisciplinary Research, University of Yamanashi)
○Yuichiro Ishii(Graduate School of Medicine, The University of Tokyo)
○Hiroyuki Okuno(Graduate School of Medical and Dental Sciences, Kagoshima University )
○Takayasu Mikuni(Brain Research Institute, Niigata University)
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Development of innovative photo-activated molecules to induce de novo synaptic plasticity in vitro and in vivo
●Ayako M. Watabe(Institute of Clinical Medicine and Research, The Jikei University)
○Manabu Abe(Brain Research Institute, Niigata University)
○Shun Hamada(Graduate Faculty of Interdisciplinary Research, University of Yamanashi)
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Study of correlative microscopy on neuronal circuits and ultrastructure
●Yusuke Hirabayashi(Graduate School of Engineering, The University of Tokyo)
○Hisato Maruoka(Graduate School of Medicine, The University of Tokyo)
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Development of data-driven integrate model using Brain/MINDS database
●Ken Nakae(Graduate School of Informatics, Kyoto Univeristy)
○Hiromichi Tsukada(Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University)
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Establishment of high efficiency method for long transgene introduction based on common marmoset
●Ikuo Tomioka(Graduate School of Science and Technology, Shinshu University )
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Advanced Multi-Linc analysis to clarify circuit mechanisms of cortical and subcortical functions
●Yoshikazu Isomura(Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)
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Efficiency improvement and standardization of cortical microcircuit analysis using 3D reconstruction of large volume EM data set
●Yoshiyuki Kubota(National Institute for Physiological Science, National Institutes of Natural Sciences)
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Development of novel optogenetic neural circuit manipulation methods by wireless power transfer system
●Itaru Imayoshi(Graduate School of Biostudies, Kyoto University)
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Development of an innovative embryo manipulating system for the generation of genetically modified marmosets
●Toshikuni Sasaoka(Brain Research Institute, Niigata University)
○Kenji Sakimura(Brain Research Institute, Niigata University)
○Ena Nakatsukasa(Brain Research Institute, Niigata University)
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Development of a method for linear modeling of brain-state and stimulus-related information
●Junichi Chikazoe(National Institute for Physiological Science, National Institutes of Natural Sciences)
○Masakazu Agetsuma(National Institute for Physiological Science, National Institutes of Natural Sciences)
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Development of innovative nanosheets for pushing the limits of deep brain imaging
●Yosuke Okamura(Department of Applied Chemistry, Tokai University)
○Yutaro Kashiwagi(Graduate School of Medicine, The University of Tokyo)
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Structural and functional mapping of brain regions controlling eye movements and cognitive functions in marmosets
●Hirotaka Onoe(Graduate School of Medicine, Kyoto Univeristy)
○Masatoshi Kasai(Graduate School of Medicine, Kyoto Univeristy)
○Tadashi Isa(Graduate School of Medicine, Kyoto Univeristy)