Understanding the cerebral cortex as a parallel circuit; elucidating construction and operating principles of the canonical circuit to establish an indicator of circuit pathology

Research Period:

FY2024-FY2026

Principal Investigator

Hisato Maruoka

Assistant professor, The University of Tokyo Graduate School of Medicine

We discovered a repetitive pattern of microcircuits composed of a small number of neurons in the output layer of the mouse cerebral cortex. A similar circuit unit has been identified in the human cerebral cortex. Through detailed analysis of this structure, we aim to understand normal cortical function and develop applications for detecting circuit dysfunction.

Co-Investigator

Yuta Nariya

Resident, Department of ophthalmology, Kameda Medical Center