Uncertainty is a key factor in human anxiety and may play a central role in anxiety disorders and depression. This study aims to investigate the neural dynamics of circuits related to uncertainty and understand its influence on decision-making in non-human primates. We will apply microelectrical stimulation to the anterior insular cortex of macaques to observe how this affects decision-making under uncertain conditions. Using fMRI, we will map cortical-subcortical networks and record neural signals from each region, aiming to clarify the neural mechanisms by which uncertainty induces anxiety.