Development of mathematical models of brain dynamics for neurodevelopmental disorders through data assimilation

Principal Investigator

Keiichi Kitajo
Professor, National Institute for Physiological Sciences, National Institute of Natural Sciences
We will measure electroencephalogram in individuals with neurodevelopmental disorders, such as those with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), as well as in neurotypical individuals and primates, under resting conditions, during cognitive tasks, and during repetitive transcranial magnetic stimulation (TMS). We aim to develop a data assimilation method that integrates these data with mathematical models, creating a digital brain that replicates the transient dynamics of brain networks. Through this digital brain, we seek to understand the pathophysiology of neurodevelopmental disorders and to validate intervention methods using repetitive TMS.

Co-Investigator

Motoaki Nakamura
Associate Professor/Deputy Director, Medical Institute of Developmental Disabilities Research, Showa University
Tomohisa Asai
Senior Researcher, Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International (ATR)
Shinya Nakamura
Project Associate Professor, Tohoku University Graduate School of Life Sciences
Hiroshi Yokoyama
Assistant Professor, Data Science and AI Innovation Research Promotion Center, Shiga University