Cross-species study of brain aging mechanisms revealed by brain connectome, genes, and individuality

Principal Investigator

Takuya Hayashi
Team Leader, RIKEN Center for Biosystems Dynamics Research
Humans are long-lived creatures capable of living beyond 100 years. Just as some people "look young" for their age, can some people have "biologically young" brains? Using RIKEN's advanced brain connectome MRI technology, this research examines aging phenomena in the brains of hundreds of participants, investigating the relationships between cognitive function, genetics, and brain connectivity. By studying these patterns in both humans and experimental animals closest to humans - non-human primates, we aim to understand the mechanisms of brain aging and develop brain-age biomarkers that could help diagnose and prevent age-related disorders and developmental conditions.

Co-Investigator

Toru Ishihara
Associate Professor, Kobe University Graduate School of Human Development and Environment
Haruto Takagishi
Professor, Brain Science Institute, Tamagawa University
Miho Inoue-Murayama
Professor, Wildlife Research Center, Kyoto University
Chihiro Yokoyama
Professor, Nara Women’s University Faculty Division of Human Life and Environmental Sciences
BAI Wenjun
Researcher, Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International(ATR)