This project aims to elucidate the accumulation and propagation mechanisms of Aβ and tau in Alzheimer's disease (AD). Using non-invasive MRI techniques, we will attempt to elucidate (i) why abnormal proteins accumulate excessively in the brain and (ii) how abnormal proteins propagate in the brain, both in the human brain and in model animals. By promoting this research, we aim to establish a pathway to the very early diagnosis of AD and the development of new treatment methods.