We will longitudinally collect MRI brain images (structural and functional images) and clinical and cognitive behavioral data from patients with mood disorders (depression, bipolar disorder) and healthy volunteers, and analyze them using the latest AI technology to clarify the macroscopic brain circuit mechanisms of depression-related symptoms and cognitive dysfunction. In addition, we will verify the causal relationship between abnormalities in brain circuit dynamics highlighted through these investigations and the pathology of depression or cognitive dysfunction through behavioral experiments and neuroimaging measurements under neural circuit manipulation in monkeys, focusing particularly on cortical-subcortical connections.