We have established a PET imaging technology that enables visualization of excitatory glutamate AMPA receptors in the living human brain (Miyazaki et al., Nature Medicine, 2020). Using this technology, we aim to investigate the expression density and distribution of AMPA receptors in the brains of dementia patients, to better understand which neural circuits are associated with cognitive impairment during the accumulation of amyloid-beta and tau, and as amyloid-beta is reduced through antibody treatment. Through this research, we aim to comprehensively elucidate the neural circuits within the human brain that determine the pathology of dementia, thereby contributing to the development of new therapeutic and diagnostic approaches.