Principal Investigator
Dai Watanabe
Professor, Kyoto University Graduate School of Medicine
In this study, we aim to develop an endomicroscopy technology, which enables long-term measuring neuronal function at a single-cell level from deep brain regions in freely behaving animals. To achieve this, we will focus on the following three objectives:
1. Developing Ca2+ imaging technology that enables long-term tracking of neural activity with a single-cell resolution.
2. Establishing action potential imaging, using genetically encoded voltage indicators (GEVIs) with high resistance to photobleaching.
3. Developing long-term measurement techniques for intracellular signaling dynamics in neuronal cells using FRET biosensors.
1. Developing Ca2+ imaging technology that enables long-term tracking of neural activity with a single-cell resolution.
2. Establishing action potential imaging, using genetically encoded voltage indicators (GEVIs) with high resistance to photobleaching.
3. Developing long-term measurement techniques for intracellular signaling dynamics in neuronal cells using FRET biosensors.