In some homeothermic species, hibernation is triggered by shortage of energy sources during the harsh winter season, resulting in an extreme hypothermic and hypometabolic state. However, neurophysiological mechanisms of hibernation remain unknown. In this project, we will employ optical imaging to analyze the neurophysiological functions of the cerebral cortex and hypothalamus during hibernation in the 'Syrian hamster' and 'hibernation model mouse', and will elucidate the neurophysiological understanding for the future of human artificial hibernation.