Intellectual deterioration may play a key role in work disturbances in patients with schizophrenia. The study demonstrated probabilistic models to estimate work status in patients with schizophrenia based on relevant factors including intellectual deterioration. Feedback on work status would support social rehabilitation in patients with schizophrenia.

The present study demonstrated that tau pathology in orbitofrontal cortex (OFC) may provoke focal neurotoxicity in OFC and the following disruption of the OFC-uncinate fasciculus network, leading to the emergence and progression of apathy in Alzheimer’s disease. The current data also raise the possibility that emerging antitau drugs would be efficacious for suppressing apathy.

By combining an 8K ultra-high-definition camera with spinning-disk one-photon confocal microscopy, we succeeded in imaging of activity of presynaptic axonal boutons of neurons projecting to the motor cortex in a behaving mouse. We detected axonal boutons with highly correlated activity over the 1 mm2 field.

This article was published in "Biochemical and Biophysical Research Communications, Volume 500, Issue 2".