
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
The International Brain Initiative (IBI) launched in 2017 brings together some of the world’s major brain research projects from the US, Europe, Canada, China, Japan, South Korea and Australia. It aims to advance ethical neuroscience research through international collaboration and knowledge sharing.
http://www.internationalbraininitiative.org
The Strategic International Brain Science Research Promotion Program (Brain/MINDS Beyond) aims at revealing human intelligence, sensitivity and sociality at the brain circuit level for the early detection and intervention of psychiatric and neurological disorders by brain imaging, studying neural circuits and developing AI-based technologies.
https://brainminds-beyond.jp
The Brain/MINDS Data Portal has been launched for sharing the data and knowledge being produced in the Brain/MINDS project.
The research highlights of the Brain/MINDS project are now available on AMED’s official YouTube channel.
A tool for calcium imaging data analyses and analysis flow administration.
The English version of ”Guidelines for the Care and Use of Nonhuman Primates in Neuroscience Research (The Japan Neuroscience Society)” is now available
2023.11.30
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Production of marmoset eggs and embryos from xenotransplanted ovary tissues
Genetically engineered animal models of marmosets are extremely useful for elucidating human diseases and developing treatments, but their creation requires many embryos. To develop a new method for producing embryos, the research group implanted marmoset ovaries under the kidney capsule of mice, harvested eggs matured by hormone administration, successfully fertilized them to produce embryos and obtained blastocysts. This is the first time in the world that a primate embryo capable of implantation in the uterus has been obtained through xenotransplantation.
2023.11.20
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Change detection in the primate auditory cortex through feedback of prediction error signals
The research group revealed that propagation of prediction error signals from higher-order auditory cortex to primary auditory cortex is critical for the change detection in the non-human primates. The feedback error signal is critical for automatic detection of unpredicted stimuli in physiological auditory processing and may serve as backpropagation-like learning.
2023.10.17
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Fluorescence radial fluctuation enables two-photon super-resolution microscopy
The research group demonstrated 2P-SRRF, a fluorescence spatiotemporal correlation analysis-based two-photon super-resolution microscopy. Application of 2P-SRRF enabled in-vivo visualization of tiny neuronal structures located at a depth of several hundred micrometers. This technique will contribute to uncovering various nanoscale biological phenomena occurring in the deep area of organisms.
2023.10.17
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A relationship between psychological difficulties and brain development in adolescence
We conducted an adolescent cohort study and found that changes in psychological difficulties from 13 to 16 years old were associated with changes in the electrophysiological index of glutamatergic neurotransmission. The results would be useful for understanding the mechanism of mental illness and contribute to the promotion of mental health in adolescence.
2023.10.16
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The research group developed a novel super-resolution two-photon excitation (2PE) microscope with all-synchronized picosecond pulse light sources and time-gated fluorescence detection, namely, all-pulsed 2PE-gSTED microscopy. This microscopy will facilitate deeper super-resolution imaging of the biological phenomena at the nanoscale in brain tissue.
2023.10.12
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The research team has succeeded in detecting the brain neuronal networks involved in trauma memory, using a novel method that combines optics and machine learning, capturing the complex changes that occur during memory formation and uncovering the mechanisms by which trauma memories are created.
2023.10.04
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Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia
The research group found a common structural footprint, a hypertrophy of the striatal medium spiny neuron (MSN) terminals, in L-DOPA-induced dyskinesia and antipsychotics-induced tardive dyskinesia. Reduced D2R signaling with repetitive dopamine fluctuations leads to VGAT overexpression in striatal MSNs, resulting in the shared structural modeling and late-onset dyskinesia formation.