Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
The International Brain Initiative (IBI) launched in 2017 brings together some of the world’s major brain research projects from the US, Europe, Canada, China, Japan, South Korea and Australia. It aims to advance ethical neuroscience research through international collaboration and knowledge sharing.
http://www.internationalbraininitiative.org
The Strategic International Brain Science Research Promotion Program (Brain/MINDS Beyond) aims at revealing human intelligence, sensitivity and sociality at the brain circuit level for the early detection and intervention of psychiatric and neurological disorders by brain imaging, studying neural circuits and developing AI-based technologies.
https://brainminds-beyond.jp
The Brain/MINDS Data Portal has been launched for sharing the data and knowledge being produced in the Brain/MINDS project.
Brain/MINDS 3D Marmoset Brain Atlas Viewer
A large effective area GaAsP PMT for wide field-of-view two-photon microscope is now available from Hamamatsu Photonics K.K.
The power of science to cure the incurable
The researchers demonstrated that mimicking a de novo mutation of the schizophrenia-risk gene SETD1A in mice induced various abnormal behaviors relevant to schizophrenia. Setd1a in postsynaptic neurons positively regulates excitatory synaptic transmission and structure in the medial prefrontal cortex through histone modification and regulating the expression of diverse synaptic genes.
Brain/MINDS DATA PORTAL・Marmoset Gene Atlas: Notice of scheduled maintenance
Due to maintenance work, we will stop our system in following period:
(1) Date (Japan time): Oct.9 (Fri), 9 a.m. – Oct.12 (Mon), 5 p.m.
(2) Date (Japan time): Oct.16 (Fri), 9 a.m. – Oct.19 (Mon), 5 p.m.
During the periods, Brain/MINDS DATA PORTAL・Marmoset Gene Atlas will not be available.
These schedules might vary depending on the situation.
Thank you for your understanding.
Brain/MINDS office
Direct and indirect pathway medium-sized spiny neurons (dMSNs and iMSNs) in the neostriatum were selectively labeled with green and red fluorescent proteins by an AAV vector. Both pathways formed two axonal arborizations in the globus pallidus external segment, and dMSN axons converged in the center of iMSN projection fields.
Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB
The researchers developed a simplified method for the production of AAV vectors, which drastically shortens the purification time from 1.5 days to 2 – 4 h. Systemic infusion of AAV-PHP.eB prepared using this method transduced whole brain. Transduction efficacy is comparable to the conventional method.
A machine learning classifier using neuroimaging data in schizophrenia, autism, and healthy controls classifies people with ultra-high risk and first episode psychosis into schizophrenia or healthy controls, but not autism.
Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases
Disruption of the FUS-SFPQ interaction was observed in a wide-range of FTLD spectrum diseases. Imbalanced ratio of tau isoforms regulated by FUS/SFPQ was observed in a wide-range of FTLD spectrum diseases as well. These results were not observed in Alzheimer disease, or Pick disease, indicating that impaired interactions of FUS/SFPQ is a common pathogenesis in FTLD spectrum diseases.
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
In this study, we generated transgenic fetal marmosets that express ARHGAP11B, a human specific gene. In the fetus brain of the transgenic marmoset, the number of bRG cells, a type of neural progenitor cell, were increased and led to an enlarged neocortex with a folded brain surface. Our study demonstrates that ARHGAP11B drives the changes in marmoset development which reflects those in the evolution of human neocortex.
