Brain Mapping by Integrated Neurotechnologies for Disease Studies

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2018.06.08
NEW

Tau steal the motivation in patients with Alzheimer’s disease.

The present study demonstrated that tau pathology in orbitofrontal cortex (OFC) may provoke focal neurotoxicity in OFC and the following disruption of the OFC-uncinate fasciculus network, leading to the emergence and progression of apathy in Alzheimer’s disease. The current data also raise the possibility that emerging antitau drugs would be efficacious for suppressing apathy.

2018.06.04
NEW

In vivo wide-field calcium imaging of mouse thalamocortical synapses
with an 8K ultra-high-definition camera

By combining an 8K ultra-high-definition camera with spinning-disk one-photon confocal microscopy, we succeeded in imaging of activity of presynaptic axonal boutons of neurons projecting to the motor cortex in a behaving mouse. We detected axonal boutons with highly correlated activity over the 1 mm2 field.

2018.05.07

A spherical aberration-free microscopy system for live brain imaging

This article was published in "Biochemical and Biophysical Research Communications, Volume 500, Issue 2".

2018.04.06

CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

Brain damage such as stroke is a devastating neurological condition, which may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic-maleate, facilitated experience-driven synaptic glutamate AMPAreceptor delivery and resulted in the acceleration of motor function recovery after brain damage in a training-dependent manner.

2016.11.02

Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) was introduced on Nature Methods

2016.09.12

Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) was introduced by Newton

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