Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
The International Brain Initiative (IBI) launched in 2017 brings together some of the world’s major brain research projects from the US, Europe, Canada, China, Japan, South Korea and Australia. It aims to advance ethical neuroscience research through international collaboration and knowledge sharing.
http://www.internationalbraininitiative.org
The Strategic International Brain Science Research Promotion Program (Brain/MINDS Beyond) aims at revealing human intelligence, sensitivity and sociality at the brain circuit level for the early detection and intervention of psychiatric and neurological disorders by brain imaging, studying neural circuits and developing AI-based technologies.
https://brainminds-beyond.jp
The Brain/MINDS Data Portal has been launched for sharing the data and knowledge being produced in the Brain/MINDS project.
Brain/MINDS 3D Marmoset Brain Atlas Viewer
In situ hybridization database
KANPHOS is an online database for phosphoproteomics involved in intracellular signal transduction in the neural system.
We improved a method of optogenetic cortical stimulation and induced overt forelimb movements in the common marmoset, a New World monkey. Our results open doors for noninvasive interrogation of motor circuits in behaving nonhuman primates to address which brain area drives hand/arm movements after learning or brain injury.
A Bayesian psychophysics model of sense of agency
Sense of agency (SoA) refers to the experience that one's own actions caused an external event. Here, the authors present a model of SoA in terms of optimal Bayesian cue integration taking into account reliability of action and outcome sensory signals and judging if the action caused the outcome.
We confirmed, for the first time, that Lewy bodies contained amyloid fibrils using autopsied brains of Parkinson's disease patients. Collaborative research with the large-scale synchrotron radiation facility, SPring-8, enabled ultrastructural analysis of aggregates in brain sections. These new findings are expected to be applied to the development of diagnostic and therapeutic approaches for Parkinson's disease.
Alzheimer’s disease protein links plaques to cell death in mice
A new protein involved in Alzheimer’s disease (AD) has been identified by researchers at the RIKEN Center for Brain Science (CBS). CAPON may facilitate the connection between the two most well-known AD culprits, amyloid plaques and tau pathology, whose interactions cause brain cell death and symptoms of dementia. This latest finding from the Takaomi Saido group at RIKEN CBS uses a novel mouse model of AD.
The study was published in Nature Communications on June 3.
We here developed a multicolor GECI suite, "XCaMP", which enables to image high-frequency firing patterns, non-invasively measure hippocampal CA1 dynamics, and simultaneously record pre- and postsynaptic firing, or co-image neuronal activities in 4 distinct celltypes. XCaMPs will be useful for elucidating complex brain circuit dynamics in health and neuropsychiatric diseases.
