The purpose of this research and development is to elucidate the human pathophysiological mechanisms underlying subtypes of psychiatric disorders through the co-creation of mathematical sciences and clinical psychiatry. To achieve this, multi-layer data will be collected and aggregated in core and aggregation sites, which will enable a smooth flow to mathematical analysis. Subsequently, data from more than 10,000 samples will undergo mathematical analysis to build pathophysiological models across multiple layers, including brain structure, function, neural circuits, molecules, and genes. From these pathophysiological models, a digital brain will be constructed, facilitating a bidirectional translational approach through collaborative research with basic neuroscience.