Elucidation of multi-layer pathogenesis and therapy development of ALS

Elucidation of human neuro-pathological mechanism for subtypes of psychiatric disorders by the co-production of mathematical science and clinical psychiatry

Understanding and regulation of glia-immune interaction and abnormal brain proteostasis in tauopathies

AMPA-PET Imaging Unveils Neural Circuitry Implicated in Dementia Pathology

Identification and intervention of pathological neural circuits in a marmoset model of Lewy Body Disease

Elucidation of the universal mechanism of neurological disease pathogenesis by endogenous DNA ligands and cellular senescence and its application to the development of therapeutic strategies

Combining tau-network mapping and genetic neuromodulation for elucidating circuit pathology and developing interventional approaches

Molecular and cellular bases for the major biotypes of schizophrenia

Study of the pathomechanisms of the prosaposin-progranulin functional network involved in Parkinson’s disease

Elucidating the Accumulation and Propagation Mechanisms of Aβ and Tau Toward Novel Therapeutic Strategies for Neurodegenerative Diseases

Elucidation of imprinting mechanisms linking Fragile X syndrome and Prader-Willi syndrome

Molecular Pathogenesis Studies of Schizophrenia Heterogeneity: Cross-Sectional and Longitudinal Perspectives

Study of the earliest intranuclear pathogenesis of the degeneration employing a novel disease model animal of ALS

Elucidation of the Pathogenesis and Development of Therapeutics for Parkinson’s Disease with focus on Type 1 Interferon

Facilitation of latent capacity based on the mechanism of functional recovery after stroke.

Molecular pathogenesis of autism spectrum disorder using human disease models

Study of the regulatory mechanism of alpha-Synuclein aggregation and propagation by astrocyte

Investigation of a novel glutamate synthesis pathway in cortical excitatory neurons and its roles in neural activity

Common pathological mechanisms across epilepsy, intellectual developmental disorders, and autoimmune neurological disorders

Mechanism of neurodegeneration and axonal dysfunction induced by RNA phase transition

Mechanisms of remyelination failure in white matter injury

Reverse-Translational Research of psychiatric disorders focusing on neuroimmune hypothesis using patient-derived cellular models

Molecular & cellular pathology of paraventricular thalamic nucleus in bipolar disorder

Elucidation of Inflammation-Driven Whole-Brain Neural Circuit Alterations in Neuropsychiatric Disorders

Multidimensional connectomics to elucidate pathophysiology of epilepsy and develop novel network neuromodulation

Elucidation of the pathophysiology of neurodevelopmental disorders stemming from dysregulated calcium signaling

Analysis of translation dynamics in psychiatric and neurological disorders to explore therapeutic targets

Elucidating the Mechanisms of Dopamine Synapse Restoration for the Development of Disease-Modifying Therapy for Parkinson’s Disease