Tauopathy is a form of neurocognitive disorder caused by the aggregation and accumulation of the protein tau in neurons. However, the pathogenic mechanism of the disease, such as how tau aggregates and accumulates and how neuronal cell death occurs, has not been clarified. We aim to understand and regulate the pathogenesis of tauopathies by elucidating the mechanisms by which proteostasis in the brain is altered.　In particular, we will focus on the interaction between neurons, glial cells, and peripheral immune cells to develop innovative drugs and disease-specific diagnostics for neurodegenerative diseases including tauopathy.