Dementia-treatment study based on cellular and molecular mechanisms of protective variants

Discovery of brain circuit biomarkers and development of neurofeedback therapy based on generative/adversarial AI and digital brains

Unleashing a New Era: Pioneering Therapies for α-Synucleinopathies

Multi-layer sequencing of germline, somatic, virus variants accelerate seeds development of autoimmune neurological diseases

Development of a comprehensive blood biomarker system capable of assessing the background pathology of dementia using PET as a reference standard

Development of Therapeutic Seeds Based on Functional Analysis of Alzheimer’s Disease Causative Genes

Proof of concept study of data-driven novel therapeutic agents for obsessive-compulsive disorder and their indication expansion

Analysis of plasma components involved in the development of dementia and development of transplantation therapy

Development of a novel therapy for tauopathy: a MARK4 inhibitor

Study of Immune Cells in Autism Spectrum Disorders

Development of Novel Brain Disease Therapy Based on the Bioprotective Effects of Senescent Microglia

Exploratory research on suppression of amyloid β aggregation by Auger electrons

Development of antisense oligonucleotides that enable highly efficient RNA editing at pathogenic point mutations

Therapeutic Strategy on neurodegenerative pathology by microglial regulation

The Potential of Olfaction in an Aging Society: Establishing Methods for Predicting and Preventing Dementia Through Scent

Study on the role of progressive complex ubiquitination in neurodegenerative diseases-associated inclusions and the disease-suppressing effects of ubiquitin ligase inhibitors

Study of EEG-NF to treat phantom limb pain

Development of diagnostic and therapeutic methods based on high-risk variants of autistic spectrum disorders using IGF-1 receptor agonists as a starting point

Identification of targets for therapeutic intervention in sporadic amyotrophic lateral sclerosis and development of drug seeds: through integrated analysis of large-scale clinical genomic information and patient-derived iPS cells/motor neurons

Innovative Early Diagnostic Development Using Integrated αSynuclein-PET/Longitudinal MRI and Acceleration of Disease-Modifying Therapy via Molecular Pathology-Based Trial-Ready Cohort in Multiple System Atrophy

Identification of extreme cases by stratification of psychiatric disorders and research on drug discovery seeds using highly validated animal and cellular models based on extreme cases

Development of an ALS/FTLD Therapy Using a Long-Acting Nucleic Acid Drug That Targets TDP-43 Phase Separation

Elucidation of the aging mechanism of fibroblasts in cerebrovascular diseases and its therapeutic application

Development of a Novel Device for Evaluating Myelin Repair and Its Application for Drug Discovery