Development of an Astrocyte-Activity-Integrated Digital Whole-Brain Dynamics Model for Predicting and Experimentally Validating Brain-State Transitions

Integrative multiscale modeling of the prefrontal cortex for understanding and treating psychiatric disorders

Development of Brain Aging Models Based on Large-Scale Neuroimaging Cohort Data and Personalized Prevention Using Digital Twins

Dissecting the mechanisms of cognitive function through optogenetic control of immediate early gene expression dynamics

The roles of the entorhinal cortex in cognitive flexibility

Development of a Novel Device for Evaluating Myelin Repair and Its Application for Drug Discovery

Elucidation of the aging mechanism of fibroblasts in cerebrovascular diseases and its therapeutic application

Development of an ALS/FTLD Therapy Using a Long-Acting Nucleic Acid Drug That Targets TDP-43 Phase Separation

Identification of extreme cases by stratification of psychiatric disorders and research on drug discovery seeds using highly validated animal and cellular models based on extreme cases

Innovative Early Diagnostic Development Using Integrated αSynuclein-PET/Longitudinal MRI and Acceleration of Disease-Modifying Therapy via Molecular Pathology-Based Trial-Ready Cohort in Multiple System Atrophy

Identification of targets for therapeutic intervention in sporadic amyotrophic lateral sclerosis and development of drug seeds: through integrated analysis of large-scale clinical genomic information and patient-derived iPS cells/motor neurons

Development of diagnostic and therapeutic methods based on high-risk variants of autistic spectrum disorders using IGF-1 receptor agonists as a starting point