◆◆◆ 第7回『Digital Brain Seminar』開催のご案内 ◆◆◆

EUのデジタル脳研究のリーダー Viktor Jirsa (Institut de Neurosciences des Systèmes)にVirtual Brain Twins in Medicineというタイトルでご発表いただきます。

7th Seminar
Speaker：Viktor Jirsa (Institut de Neurosciences des Systèmes)
Place : Zoom (Please find the zoom link by the registration)
Date：2024/11/12 Tue 18:00-19:30 (JST)
Title：Virtual Brain Twins in Medicine
Abstract : In the past twenty years, we have made significant progress in creating digital models of an individual’s brain, so called virtual brain twins. By combining brain imaging data with mathematical models, we can predict outcomes more accurately than using each method separately. Our approach has helped us understand normal brain states, their operation and conditions like healthy aging, dementia and epilepsy. Using a combination of computational modeling and dynamical systems analysis we provide a mechanistic description of the formation of resting state manifold via the network connectivity. We demonstrate that the symmetry breaking by the connectivity creates a characteristic flow on the manifold, which produces the major data features across scales and imaging modalities. These include spontaneous high amplitude co-activations, neuronal cascades, spectral cortical gradients, multistability, and characteristic functional connectivity dynamics. When aggregated across cortical hierarchies, these match the profiles from empirical data and explain features of the brain’s microstate organization. The digital brain twin augments the value of empirical data by completing missing data, allowing clinical hypothesis testing and optimizing treatment strategies for the individual patient. Virtual Brain Twins are part of the European infrastructure called EBRAINS, which supports researchers worldwide in digital neuroscience.