
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
The International Brain Initiative (IBI) launched in 2017 brings together some of the world’s major brain research projects from the US, Europe, Canada, China, Japan, South Korea and Australia. It aims to advance ethical neuroscience research through international collaboration and knowledge sharing.
http://www.internationalbraininitiative.org
The Strategic International Brain Science Research Promotion Program (Brain/MINDS Beyond) aims at revealing human intelligence, sensitivity and sociality at the brain circuit level for the early detection and intervention of psychiatric and neurological disorders by brain imaging, studying neural circuits and developing AI-based technologies.
https://brainminds-beyond.jp
The Brain/MINDS Data Portal has been launched for sharing the data and knowledge being produced in the Brain/MINDS project.
Brain/MINDS 3D Marmoset Brain Atlas Viewer
A tool for calcium imaging data analyses and analysis flow administration.
The English version of ”Guidelines for the Care and Use of Nonhuman Primates in Neuroscience Research (The Japan Neuroscience Society)” is now available
In collaboration with Brain/MINDS Beyond and the Johns Hopkins of Medicine, the research group developed non-invasive high-resolution brain imaging for studying the neural circuits of various primate species. This valuable resource enhances our understanding of the human brain and neurological conditions through data-driven research. The findings have been published in Neuroimage as an invited article.
Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy
Epilepsy is a neurological disorder characterized by seizures due to excessive electrical activity in the brain. However, the precise mechanisms underlying the pathogenesis of epilepsy remain unknown. Using a novel radiotracer, [11C]K-2, the first technology to visualize and quantify α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in the living human brain, researchers have been able to offer insight into the role of AMPA receptor trafficking in epileptogenesis. Their findings could lead to the development of novel therapeutics for patients with epilepsy.
Local and long-distance organization of prefrontal cortex circuits in the marmoset brain
We performed systematic whole brain connectivity mapping of the marmoset prefrontal cortex (PFC) and found two types of projections (patchy and diffuse), which were topographically arranged in the cortex and striatum. We expect this new resource to deepen our understanding of the local and long-range connectivity of the primate PFC.
Employing transcranial focused ultrasound combined with intravenously administered microbubbles, a novel technique was established to deliver systemically injected adeno-associated virus vector selectively into particular brain regions of macaques through transient opening of the blood-brain barrier. This may be a viable tool to express target genes focally and non-invasively, contributing to the development of therapeutic approaches against neurodegenerative disorders.
Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range
Using magnetic resonance imaging (MRI), we have developed and released a digital brain database of the common marmoset, a small primate. It contains a wide range of information such as age, sex, and body size (weight), and is currently the world's largest public database of common marmoset brains.
We found that decreased inhibitory-self connection of the Limbic network was the common aberrant large-scale network interaction across schizophrenia, major depressive disorder and bipolar disorder by applying dynamic causal modeling to the multi-site resting-state fMRI datasets. This would lead to the elucidation of the pathophysiological mechanisms for the psychiatric disorders.
We developed a new strategy termed flip-excision switch (FLEX) system with unilateral spacer sequence (USS) by using AAV vector for a precise and selective control of transgene expression in target cell populations. The FLEX/USS system will enable us a detailed understanding of the structure and function of specific neural circuits.