Brain Mapping by Integrated Neurotechnologies for Disease Studies

Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

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The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: The second phase of the archive of digital records

In collaboration with Brain/MINDS Beyond and the Johns Hopkins of Medicine, the research group developed non-invasive high-resolution brain imaging for studying the neural circuits of various primate species. This valuable resource enhances our understanding of the human brain and neurological conditions through data-driven research. The findings have been published in Neuroimage as an invited article.


Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy

Epilepsy is a neurological disorder characterized by seizures due to excessive electrical activity in the brain. However, the precise mechanisms underlying the pathogenesis of epilepsy remain unknown. Using a novel radiotracer, [11C]K-2, the first technology to visualize and quantify α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in the living human brain, researchers have been able to offer insight into the role of AMPA receptor trafficking in epileptogenesis. Their findings could lead to the development of novel therapeutics for patients with epilepsy.


Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

We performed systematic whole brain connectivity mapping of the marmoset prefrontal cortex (PFC) and found two types of projections (patchy and diffuse), which were topographically arranged in the cortex and striatum. We expect this new resource to deepen our understanding of the local and long-range connectivity of the primate PFC.


BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

Employing transcranial focused ultrasound combined with intravenously administered microbubbles, a novel technique was established to deliver systemically injected adeno-associated virus vector selectively into particular brain regions of macaques through transient opening of the blood-brain barrier. This may be a viable tool to express target genes focally and non-invasively, contributing to the development of therapeutic approaches against neurodegenerative disorders.


Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range

Using magnetic resonance imaging (MRI), we have developed and released a digital brain database of the common marmoset, a small primate. It contains a wide range of information such as age, sex, and body size (weight), and is currently the world's largest public database of common marmoset brains.


Aberrant large-scale network interactions across psychiatric disorders revealed by large-sample multi-site resting-state functional magnetic resonance imaging datasets

We found that decreased inhibitory-self connection of the Limbic network was the common aberrant large-scale network interaction across schizophrenia, major depressive disorder and bipolar disorder by applying dynamic causal modeling to the multi-site resting-state fMRI datasets. This would lead to the elucidation of the pathophysiological mechanisms for the psychiatric disorders.


Development of a new viral vector strategy for a precise and selective control of transgene expression through Cre-dependent gene switch system

We developed a new strategy termed flip-excision switch (FLEX) system with unilateral spacer sequence (USS) by using AAV vector for a precise and selective control of transgene expression in target cell populations. The FLEX/USS system will enable us a detailed understanding of the structure and function of specific neural circuits.


Past events

Related Projects

  • International Brain Initiative
  • Marmoset Gene Atlas
  • Brain/MINDS Data Portal

Supported by

Japan Agency for Medical Research and Development