Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

Brain/MINDS project web site

News

2019.04.25
NEW

Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model

In the neonatal autism-model marmoset, we showed a significant reduction of anterior commissure, which connected bilateral social brains. Abnormal expression of axon guidance molecules mediating formation of anterior commissure were also observed in this animal-model. These features might be useful for early diagnosis and early intervention/ therapy of human autism.

2019.03.04

Neuroethical Issues of the Brain/MINDS Project of Japan

The Brain/MINDS project aims to further understand the human brain and neuropsychiatric disorders through ‘‘translatable’’ biomarkers. Here, we describe the neuroethical issues of the project that have arisen from clinical data collection and the use of biological models of neuropsychiatric disorders.

2019.03.04

Mismatch negativity (MMN) as a tool for translational investigations into early psychosis: a review

Mismatch negativity (MMN) reduction is one of the most robust findings in schizophrenia that is related with early psychosis, functional abilities and translatable into animal models. We reviewed clinical MMN research and basic research in animal models and human intracranial recording for understanding neural mechanism of MMN.

2019.03.01

Gamma-band auditory steady-state response is associated with plasma levels of D-serine in schizophrenia: an exploratory study

We demonstrated that the gamma-band auditory steady-state response (ASSR), which is significantly impaired in patients with schizophrenia compared with healthy controls, is significantly correlated with plasma levels of D-serine, a co-agonist of the glycine binding site of N-methyl-D-aspartate (NMDA) receptor, in the schizophrenia group. These findings suggest that the gamma-band ASSR may reflect NMDA receptor function in schizophrenia.

2019.03.01

A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

We developed a high-throughput neurohistological and computational pipeline to accurately map individual brains into a common reference atlas. This method uses a grid-based tracer injection strategy for systematic mesoscale connectivity mapping, providing the first detailed and large-scale presentation of a full resolution microscopic online database (http://marmoset.brainarchitecture.org/). Our method will lay a foundation for subsequent scientific outputs and help others establish their own workflows in the future.

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