Brain Mapping by Integrated Neurotechnologies for Disease Studies

Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

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2020.09.17
NEW

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities

The researchers demonstrated that mimicking a de novo mutation of the schizophrenia-risk gene SETD1A in mice induced various abnormal behaviors relevant to schizophrenia. Setd1a in postsynaptic neurons positively regulates excitatory synaptic transmission and structure in the medial prefrontal cortex through histone modification and regulating the expression of diverse synaptic genes.

2020.09.16
NEW

Brain/MINDS DATA PORTAL・Marmoset Gene Atlas: Notice of scheduled maintenance

Due to maintenance work, we will stop our system in following period:
(1) Date (Japan time): Oct.9 (Fri), 9 a.m. – Oct.12 (Mon), 5 p.m.
(2) Date (Japan time): Oct.16 (Fri), 9 a.m. – Oct.19 (Mon), 5 p.m.

During the periods, Brain/MINDS DATA PORTAL・Marmoset Gene Atlas will not be available.

These schedules might vary depending on the situation.
Thank you for your understanding.
Brain/MINDS office

2020.09.04
NEW

Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment

Direct and indirect pathway medium-sized spiny neurons (dMSNs and iMSNs) in the neostriatum were selectively labeled with green and red fluorescent proteins by an AAV vector. Both pathways formed two axonal arborizations in the globus pallidus external segment, and dMSN axons converged in the center of iMSN projection fields.

2020.09.03
NEW

Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB

The researchers developed a simplified method for the production of AAV vectors, which drastically shortens the purification time from 1.5 days to 2 – 4 h. Systemic infusion of AAV-PHP.eB prepared using this method transduced whole brain. Transduction efficacy is comparable to the conventional method.

2020.08.21

Machine-learning classification using neuroimaging data in schizophrenia, autism, ultra-high risk and first-episode psychosis

A machine learning classifier using neuroimaging data in schizophrenia, autism, and healthy controls classifies people with ultra-high risk and first episode psychosis into schizophrenia or healthy controls, but not autism.

2020.08.13

Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases

Disruption of the FUS-SFPQ interaction was observed in a wide-range of FTLD spectrum diseases. Imbalanced ratio of tau isoforms regulated by FUS/SFPQ was observed in a wide-range of FTLD spectrum diseases as well. These results were not observed in Alzheimer disease, or Pick disease, indicating that impaired interactions of FUS/SFPQ is a common pathogenesis in FTLD spectrum diseases.

2020.07.21

Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset

In this study, we generated transgenic fetal marmosets that express ARHGAP11B, a human specific gene. In the fetus brain of the transgenic marmoset, the number of bRG cells, a type of neural progenitor cell, were increased and led to an enlarged neocortex with a folded brain surface. Our study demonstrates that ARHGAP11B drives the changes in marmoset development which reflects those in the evolution of human neocortex.

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Related Projects

  • International Brain Initiative
  • Marmoset Gene Atlas
  • Brain/MINDS Data Portal

Supported by

Japan Agency for Medical Research and Development