Researchers at the University of Tsukuba and the National Institutes for Quantum Science and Technology (QST) have developed TAME-Q, open-source software that automates the processing and semi-quantification of florzolotau (18F) PET images. When applied to a single-center dataset of 133 participants, TAME-Q produced results consistent with those of a previously established workflow. The software is expected to support reproducible research on tauopathies such as Alzheimer’s disease and progressive supranuclear palsy.