Development and provision of adeno-associated virus vectors optimized for marmoset brain research

Research period : 2021-2023
Principal Investigator
平井 宏和

Hirokazu Hirai

Graduate School of Medicine, Gunma University

In this research project, we produce various capsid-coated adeno-associated virus (AAV) vectors carrying different cell type–specific enhancers/promoters and assess their transduction properties in the marmoset cerebral cortex. In addition, we conduct screening of the AAV capsid library to find capsid variants that efficiently penetrate the marmoset blood-brain barrier. We will disclose the data swiftly to Brain/MINDS researchers, and provide AAV vectors to researchers upon request.