Establishment of high efficiency method for long transgene introduction based on common marmoset

Research period : 2019-2021
Principal Investigator
富岡 郁夫

Ikuo Tomioka

Graduate School of Science and Technology, Shinshu University

Lentiviral gene transfer is a powerful tool in the genetic modification of animal genomes and is the most efficient method for creating transgenic marmosets. However, the transgene length in lentiviral vectors is strictly limited making it impossible to produce marmoset models for most neurodegenerative diseases. Therefore, this research will establish a highly efficient method for long transgene introduction using the transposon system of common marmosets.