Molecular mechanisms of spreading of TDP-43 pathology

Principal Investigator
長谷川 成人

Masato Hasegawa

Tokyo Metropolitan Institute of Medical Science, Department of Dementia and Higher Brain Function

To investigate the molecular mechanisms of TDP-43 accumulation in cells,we will identify the regions and the sequences responsible for TDP-43 aggregation, and establish the cellular models of seeded aggregation of TDP- 43. Furthermore,we will inoculate these abnormal proteins (tau, alpha-synuclein and TDP-43,etc) into brains of mice and marmosets,and analyze the spreading of the abnormal lesions by immunohistochemistry.