Molecular mechanisms of spreading of TDP-43 pathology

To investigate the molecular mechanisms of TDP-43 accumulation in cells，we will identify the regions and the sequences responsible for TDP-43 aggregation, and establish the cellular models of seeded aggregation of TDP- 43. Furthermore，we will inoculate these abnormal proteins (tau, alpha-synuclein and TDP-43，etc) into brains of mice and marmosets，and analyze the spreading of the abnormal lesions by immunohistochemistry.