Developing innovative therapeutic interventions for frontotemporal lobar degeneration based on the elucidation of neural circuit disruption

In this project, we take charge of developing innovative therapeutic interventions for FTLD-ALS based on the elucidation of neuronal circuits break­down. Our mission is 1) to identify the specific early macro brain network disruption in FTLD/ALS patients; 2) to establish the translatable indicator leading to the clarification of ultra-early neuronal circuit involvement and subsequent progression by establishment of TDP-43/FUS mouse models; 3) to accelerate the development of novel diagnostic tool and treatment by validating the human and mouse findings using common marmoset models.