Translational research for neuronal circuitry pathologies of Parkinson’s and cerebrovascular diseases

The goal of this study is to develop the novel translatable biomarkers for presymptomatic, very early or recovery stage in Parkinson’s disease (PD). We have established human α-synuclein BAC transgenic mouse model, α-synuclein propagation model and drug-induced model of PD. In order to elucidate the mechanisms of neuronal circuitry rewiring in PD associated with the onset and progression of the symptoms and compensatory actions of the brain, we are going to analyze the neuronal circuitry pathology of these mouse model throughout the disease progression by using in vivo two-photon imaging.