Understand the hallucination and delusion mechanism of schizophrenia from replay brain activities using a connectome dynamics model

Research Period:
FY2025-FY2027

Principal Investigator

Yusuke Takeda
Senior Researcher, Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International
Schizophrenia is a mental disorder characterized by hallucinations and delusions. To elucidate the mechanisms underlying these symptoms, this study focuses on replay brain activity, which is assumed to contribute to the formation of memory and cognition. We develop digital brain models that replicate such replay activity and simulate how information distributed across the brain is integrated to generate cognition through replay.