In recent years, the role of inflammation and neural circuit remodeling in neuropsychiatric disorders has drawn increasing attention, though their relationship remains poorly understood. In this project, we will use mouse models of neuropsychiatric disorders in which inflammation is involved, such as those induced by chronic stress or aging, to visualize and manipulate inflammation-induced neural circuit remodeling to elucidate its mechanisms. We will also analyze brain imaging data from patients with diverse neuropsychiatric disorders and examine their relationship with inflammation-related molecules and cells in peripheral blood. Through these basic and clinical approaches, we aim to contribute to the identification of novel biomarkers and therapeutic targets.