Human brains differ in the structure and function from animal model brains. Thus, the molecular-anatomical knowledge about synaptic diversity in the human brain is essential for understanding human brain dynamics. By fixing human post-mortem brains with fixatives suitable for immunohistochemical detections of synaptic molecules, our research project aims to create a comprehensive map of human brain synaptome, which represents the molecular profiles of individual synapses in brain tissues. This will help reveal the molecular-anatomical basis and functional roles of human-specific synapses in the brain dynamics.