Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Organization

(As of November 1, 2017)

Core Institute (RIKEN)

Team A
Structure and functional mapping of the non-human primate brain

  • Hideyuki Okano
    BSI, Marmoset Neural Architecture
    School of Medicine, Keio University
  • Tetsuo Yamamori
    BSI, Molecular Analysis of Higher Brain Function
  • Noritaka Ichinohe
    BSI, Molecular Analysis of Higher Brain Function
  • Tomomi Shimogori
    BSI, Molecular Mechanisms of Thalamus Development
  • Atsushi Iriki
    BSI, Symbolic Cognitive Development
  • Takaomi C. Saido
    BSI, Proteolytic Neuroscience
  • Takuya Hayashi
    Functional Architecture Imaging Team
    Center for Life Science Technologies
  • Partha Mitra
    BSI, Marmoset Neural Architecture
    Cold Spring Harbor Laboratory

Team B
Development of novel, cutting-edge technologies that support brain mapping

  • Atsushi Miyawaki
    BSI, Molecular Analysis of Higher Brain Function
  • Keiji Tanaka
    BSI, Cognitive Brain Mapping
  • Yukiko Goda
    BSI, Synaptic Plasticity and Connectivity
  • Taro Toyoizumi
    BSI, Neural Computation and Adaption
  • Shigeyoshi Fujisawa
    BSI, Systems Neurophysiology
  • Masanori Murayama
    BSI, Behavioral Neurophysiology
  • Tomoki Fukai
    BSI, Neural Circuit Theory
  • Yoko Yamaguchi
    BSI, Neuroinformatics Japan Center
  • Hideo Yokota
    RAP, Image Processing Research Team

Partner Institutes
(Keio Uni/Kyoto Uni)

Innovative approaches for the compilation of non-human primate brain map

  • Shinsuke Shibata
    Keio University School of Medicine, Electron Microscope Laboratory

Neural networks underlying higher brain functions in common marmosets

  • Katsuki Nakamura
    Prime Research Institute, Kyoto University

Management Team

Translation between brain maps in primates and brain circuits in patients with neuropsychiatric disorders using integrative neuroimaging data resources

  • Kiyoto Kasai
    Graduate School of Medicine,
    The University of Tokyo

Elucidation of pathological neural network via imaging genetics analysis for mental disorders

  • Norio Ozaki
    Graduate School of Medicine,
    Nagoya University,Department of Psychiatry&
    Department of Child and Adolescent Psychiatry

Elucidation of neural circuit responsible for cognition and behavior in disease pathology

  • Ryota Hashimoto
    United Graduate School of Child Development, Osaka University

The research on neural circuit of neuropsychiatric disorders – molecular mechanism and modeling

  • Tetsuya Suhara
    National Institutes for Quantum and Radiological Science and Technology,
    National Institute of Radiological Sciences

Acquisition of detailed functional and structural brain images of human healthy subjects for promotion of understanding brain circuits of the marmoset, a new animal model for neuropsychiatric diseases

  • Kenji Matsumoto
    Brain Science Institute, Tamagawa University

Identification of disease-common neural circuit abnormalities

  • Tetsuo Kobayashi
    Graduate School of Engineering,
    Kyoto University

Disease Research Team
(Neuropsychiatric Disorders)

Translation between brain maps in primates circuits in patients with neuropsychiatric disorders using integrative neuroimaging data resources

  • Kiyoto Kasai
    Graduate School of Medicine,
    The University of Tokyo

Elucidation of pathological neural network via identification of rare genomic variants associated with mental disorders

  • Norio Ozaki
    Graduate School of Medicine,
    Nagoya University, Department of Psychiatry & Department of Child and Adolescent Psychiatry

Elucidation of neural circuit responsible for cognition and behavior in disease pathology

  • Ryota Hashimoto
    United Graduate School of Child Development,
    Osaka University

The research on neural circuit of neuropsychiatric disorders – molecular mechanism and modeling

  • Tetsuya Suhara
    National Institutes for Quantum and Radiological Science and Technology,
    National Institute of Radiological Sciences

Investigation of altered neural circuits in autism spectrum disorder and schizophrenia using multimodal MRI and development of cross-species translatable measures of brain functions

  • Ryuichiro Hashimoto
    Medical Institute of Developmental Disabilities Research,
    Showa University Karasuyama Hospital

Neural pathways for saliency detection during free-viewing

  • Masatoshi Yoshida
    National Institute for Physiological Science,
    National Institutes of Natural Sciences

Elucidation of neural networks associated with mood disorders by analyzing neuroimaging

  • Yasumasa Okamoto
    Graduate School of Biomedical Sciences,
    Hiroshima University

Analysis of molecular-motor in animal models

  • Yosuke Takei
    University of Tsukuba

Disease Research Team
(Cerebrovascular Disease and others)

Translational research for neuronal circuitry pathologies of Parkinson’s and cerebrovascular diseases

  • Ryosuke Takahashi
    Department of Neurology
    Kyoto University Graduate School of Medicine

Identification of mechanism for motor paralysis and higher brain dysfunction after cerebrovascular disorder,and establishment the translatable biomarkers for their functional recovery using nonhuman primate model

  • Tadashi Isa
    Department of Neuroscience,
    Graduate School of Medicine, Kyoto University

Elucidation of injured neural networks and their compensatory mechanisms due to the acute and chronic neurological disorders

  • Miho Murata
    National Center Hospital,
    National Center of Neurology and Psychiatry

Development of PET probes to detect synaptic proteins

  • Takuya Takahashi
    Yokohama City University,
    Graduate School of Medicine

The ultrastructural identification of translatable biomarkers for the diagnosis of the early stages of Parkinson’s disease and related disorders

  • Masato Koike
    Juntendo University,
    Graduate School of Medicine

The analysis of pathological neural networks in the patients with movement disorders and animal disease models

  • Toshiki Yoshimine
    Global Center for Medical Engineering and Informatics, Osaka University

Disease Research Team
(Neurodegenerative Disease)

Comprehensive researches to elucidate neuro-network dysfunctions in neurodegenerative dementia

  • Hitoshi Okazawa
    Medical Research Institute / Center for Brain Integrative Research,
    Tokyo Medical and Dental University

Identification of damaged neuronal circuits in very early Alzheimer disease patients and elucidation of molecular mechanism of tau pathology spreading

  • Taisuke Tomita
    Graduate School of Pharmaceutical Sciences,The University of Tokyo

Developing innovative therapeutic interventions for frontotemporal lobar degeneration based on the elucidation of neural circuit disruption

  • Gen Sobue
    Graduate School of Medicine,Nagoya University

Multiple molecular and radiological analysis of Parkinson’s disease pathogenesis based on patients and animal models

  • Nobutaka Hattori
    Juntendo University,
    Graduate School of Medicine

Detection of a key neural circuit in very early stage of Alzheimer’s disease

  • Hiroshi Matsuda
    Integrative Brain Imaging Center,
    National Center of Neurology and Psychiatry

Translatable imaging and mechanistic controls of a pathological cascade in age-related neurodegenerative conditions

  • Makoto Higuchi
    National Institutes for Quantum and Radiological Science and Technology,
    National Institute of Radiological Sciences

Molecular mechanisms of spreading of TDP-43 pathology

  • Masato Hasegawa
    Tokyo Metropolitan Institute of Medical Science,
    Department of Dementia and Higher Brain Function

Development of novel cutting edge technologies

Ultra-thin Electronic Sensor System for Marmoset’s Brain Signal measurement

  • Tsuyoshi Sekitani
    The Institute of Scientific and Industrial Research,
    Osaka University

A novel multi-neuronal recording with optogenetic identification of axonal projections

  • Yoshikazu Isomura
    Brain Science Institute,
    Tamagawa University

Computational frameworks for multi-scale models using structural and functional brain map data

  • Kenji Doya
    Neural Computation Unit,
    Okinawa Institute of Science and Technology
    Graduate University

Development of the marmoset embryo-manipulating technologies for efficient generation of knock-in animals and reduction of generation interval

  • Atsu Aiba
    Graduate School of Medicine,
    The University of Tokyo
  • Atsuo Ogura
    Bioresource Engineering Division,
    RIKEN BioResource Center

Development of optical techniques to manipulate and measure cortical circuits with higher brain functions

  • Masanori Matsuzaki
    Graduate School of Medicine,
    The University of Tokyo

Fast 3D recording of neuronal activity and long-term imaging of activity traces through development of innovative probing technologies

  • Haruhiko Bito
    Graduate School of Medicine,
    The University of Tokyo
  • Kazuo Kitamura
    Graduate School Department of Interdisciplinary Research,
    University of Yamanashi

Development of super-resolution multi-photon microscopy by utilizing a novel semiconductor based light source

  • Tomomi Nemoto
    Research Institute for Electronic Science,
    Hokkaido University
  • Hiroyuki Yokoyama
    New Industry Creation Hachery Center,
    Tohoku University

New Technology Innovation

Multimodal multi-scale functional mapping of marmoset brain and development of functional mapping at ultra-fine scale

  • Kenichi Ohki
    Graduate School of Medicine,
    The University of Tokyo

Analyze structures and functions of marmoset brains by multi-scale and multi-modal approaches

  • Atsushi Nambu
    National Institute for Physiological Sciences,
    National Institutes for Natural Sciences
  • Hajime Mushiake
    School of Medicine,
    Tohoku University

AAV vector-mediated cell type-specific gene knock-down / knock-out in marmoset CNS in vivo

  • Hirokazu Hirai
    Graduate School of Medicine,
    Gunma University

Mapping the structure and function of the cortico-basal ganglia network in marmosets by use of pathway-specific labeling and manipulation technology

  • Kazuto Kobayashi
    School of Medicine,
    Fukushima Medical University
  • Miwako Yamasaki
    Faculty of Medicine,
    Hokkaido University

Production of knockout marmoset using spermatogenic cells

  • Takashi Shinohara
    Graduate School of Medicine,
    Kyoto University

Zoom-in to the ultrastructure level from the whole brain level using a tissue-clearing method as the cornerstone

  • Hiroyuki Hioki
    School of Medicine,
    Juntendo University
  • Takahiro Furuta
    Graduate School of Dentistry,
    Osaka University

Development of neural circuit tracing for mapping the connectome in the common marmoset

  • Fumitaka Osakada
    Graduate School of Pharmaceutical Sciences,
    Nagoya University

Development of innovative method for an all-optical electrophysiology to measure and manipulate neural activity.

  • Masayuki Sakamoto
    Graduate School of Medicine,
    The University of Tokyo
  • Yuki Sudo
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
    Okayama University

Development of innovative wide-view mapping of synaptic ensemble in the psychiatric model

  • Akiko Hayashi-Takagi
    Lab of Medical Neuroscience,
    Institution of Molecular and Cellular Regulation,
    Gunma University

Development of 3D imaging and analysis pipeline for marmoset brain

  • Hiroki R. UEDA
    Graduate School of Medicine,
    The University of Tokyo

Super-multicolor labeling for automatic reconstruction of neuronal circuits

  • Takeshi Imai
    Graduate School of Medical Sciences,
    Kyushu University

Development of a method for high speed and high resolution whole-brain imaging in primates

  • Hitoshi Hashimoto
    Graduate School of Pharmaceutical Sciences,
    Osaka University