Brain Mapping by Integrated Neurotechnologies for Disease Studies

Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

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Brain/MINDS DATA PORTAL・Marmoset Gene Atlas: Notice of scheduled maintenance

Due to maintenance work, we will stop our system in following period:
(1) Date (Japan time): Oct.8 (Fri), 9 a.m. – Oct.1 (Mon), 5 p.m.
(2) Date (Japan time): Oct.15 (Fri), 9 a.m. – Oct.18 (Mon), 5 p.m.

During the periods, Brain/MINDS DATA PORTAL・Marmoset Gene Atlas will not be available.

These schedules might vary depending on the situation.
Thank you for your understanding.
Brain/MINDS office


Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease

In the cortex of a marmoset model of autism exposed to valproic acid in utero, genes associated with neurons and oligodendrocytes were down-regulated, and genes associated with microglia and astrocytes were up-regulated, as in human autism. However, the current major rodent models could only reproduce human autism in at most two of the four cell types of the brain. This confirms the prediction that primate autism models reproduce human autism better than rodent models by an objective method of transcriptome comparison.


Current Status of and Perspectives on the Application of Marmosets in Neurobiology

The common marmoset (Callithrix jacchus), a small New World primate, is receiving substantial attention in the neuroscience and biomedical science fields because its anatomical features, functional and behavioral characteristics, and reproductive features and its amenability to available genetic modification technologies make it an attractive experimental subject. This review outlines the progress of marmoset neuroscience research and summarizes both the current status (opportunities and limitations) of and the future perspectives on the application of marmosets in neuroscience and disease modeling.


A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide

The researchers generated a new Alzheimer’s disease (AD) mouse model that more faithfully recapitulate pathology of AD patients compared to the previous ones. This new third-generation mouse model will help accelerate the elucidation of the disease mechanisms and development of disease-modifying therapies to treat AD.


Altered Dynamic Information Flow through the Cortico-Basal Ganglia Pathways Mediates Parkinson’s Disease Symptoms

By recording neuronal activity from a Japanese monkey model of Parkinson’s disease, the researchers have elucidated the neural mechanisms underlying parkinsonian symptoms. Disturbance of information flow through the “direct pathway” in the basal ganglia is responsible for parkinsonian symptoms, and its restoration has beneficial effects on the symptoms.


Past events

Related Projects

  • International Brain Initiative
  • Marmoset Gene Atlas
  • Brain/MINDS Data Portal

Supported by

Japan Agency for Medical Research and Development