Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
Brain Mapping by Integrated Neurotechnologies for Disease Studies
Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.
The International Brain Initiative (IBI) launched in 2017 brings together some of the world’s major brain research projects from the US, Europe, Canada, China, Japan, South Korea and Australia. It aims to advance ethical neuroscience research through international collaboration and knowledge sharing.
http://www.internationalbraininitiative.org
The Strategic International Brain Science Research Promotion Program (Brain/MINDS Beyond) aims at revealing human intelligence, sensitivity and sociality at the brain circuit level for the early detection and intervention of psychiatric and neurological disorders by brain imaging, studying neural circuits and developing AI-based technologies.
https://brainminds-beyond.jp
The Brain/MINDS Data Portal has been launched for sharing the data and knowledge being produced in the Brain/MINDS project.
Brain/MINDS 3D Marmoset Brain Atlas Viewer
A large effective area GaAsP PMT for wide field-of-view two-photon microscope is now available from Hamamatsu Photonics K.K.
The English version of ”Guidelines for the Care and Use of Nonhuman Primates in Neuroscience Research (The Japan Neuroscience Society)” is now available
Brain/MINDS DATA PORTAL・Marmoset Gene Atlas: Notice of scheduled maintenance
Due to maintenance work, we will stop our system in following period:
(1) Date (Japan time): Oct.8 (Fri), 9 a.m. – Oct.1 (Mon), 5 p.m.
(2) Date (Japan time): Oct.15 (Fri), 9 a.m. – Oct.18 (Mon), 5 p.m.
During the periods, Brain/MINDS DATA PORTAL・Marmoset Gene Atlas will not be available.
These schedules might vary depending on the situation.
Thank you for your understanding.
Brain/MINDS office
In the cortex of a marmoset model of autism exposed to valproic acid in utero, genes associated with neurons and oligodendrocytes were down-regulated, and genes associated with microglia and astrocytes were up-regulated, as in human autism. However, the current major rodent models could only reproduce human autism in at most two of the four cell types of the brain. This confirms the prediction that primate autism models reproduce human autism better than rodent models by an objective method of transcriptome comparison.
Current Status of and Perspectives on the Application of Marmosets in Neurobiology
The common marmoset (Callithrix jacchus), a small New World primate, is receiving substantial attention in the neuroscience and biomedical science fields because its anatomical features, functional and behavioral characteristics, and reproductive features and its amenability to available genetic modification technologies make it an attractive experimental subject. This review outlines the progress of marmoset neuroscience research and summarizes both the current status (opportunities and limitations) of and the future perspectives on the application of marmosets in neuroscience and disease modeling.
The researchers generated a new Alzheimer’s disease (AD) mouse model that more faithfully recapitulate pathology of AD patients compared to the previous ones. This new third-generation mouse model will help accelerate the elucidation of the disease mechanisms and development of disease-modifying therapies to treat AD.
By recording neuronal activity from a Japanese monkey model of Parkinson’s disease, the researchers have elucidated the neural mechanisms underlying parkinsonian symptoms. Disturbance of information flow through the “direct pathway” in the basal ganglia is responsible for parkinsonian symptoms, and its restoration has beneficial effects on the symptoms.
