Brain Mapping by Integrated Neurotechnologies for Disease Studies

Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

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2022.06.28
NEW

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder

Copy number variation (CNV) analysis of bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD) revealed that small (<100 kb) deletions are more common in BD and large (>500 kb) CNVs are more common in SCZ/ASD. Known risk CNVs for neurodevelopmental disorders were associated with the three disorders, but their impact on BD risk was relatively small. Chromatin function was involved in BD, while broader and overlapping molecular mechanisms were involved in SCZ/ASD. CNVs in non-coding regions were associated with risk of SCZ/ASD.

2022.05.06

Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia

A chemogenetic tool was applied to macaque monkeys, and activity in the subthalamic nucleus, a part of the basal ganglia, was suppressed. During suppression, monkeys’ reaching movements became unstable, and involuntary movements were induced. In the output nucleus of the basal ganglia, the internal pallidum, neurons showed no firing rate change, but their spike train became variable. The subthalamic nucleus may stabilize neural activity in the basal ganglia for smooth movements.

2022.05.06

Subthalamic nucleus deep brain stimulation driven by primary motor cortex γ2 activity in parkinsonian monkeys

Deep brain stimulation (DBS), applying electric stimulation to the subthalamic nucleus, can effectively treat advanced Parkinson’s disease. Both adaptive DBS (aDBS) driven by primary motor cortical activity and conventional constant DBS (cDBS) significantly decreased reaction and movement times in parkinsonian monkeys. The electric charge delivered with aDBS was lower than that with cDBS. aDBS is an effective therapeutic approach with lower electrical requirements.

2022.03.24

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

Researchers from Osaka University discovered a small group of brain cells in the claustrum of mice that bidirectionally controls stress-induced anxiety behaviors. Deactivation of these cells made mice more resilient against chronic stress. These findings could be the key to understanding the cause of stress-related disorders.

2022.03.08

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

Tau present in the extracellular fluids has a critical role in the pathogenesis of tauopathies. The authors describe that glymphatic clearance of extracellular tau impacts tau accumulation and neurodegeneration. The study implicates glymphatic system in the pathophysiology of tauopathies.

2022.02.21

A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo

The researchers developed a Rosa26 knockin mouse that expresses a green calcium indicator (G-CaMP9a) with fast kinetics and a high signal-to-noise ratio. This reporter mouse allows for the investigation of neuronal activity in defined cell populations and will facilitate dissecting complex dynamics of neural networks in vivo.

2022.02.21

Brain/MINDS DATA PORTAL・Marmoset Gene Atlas: Notice of scheduled maintenance

 

Due to maintenance work, we will stop our system in following period:
Date (Japan time): February 24th (Thu), 1:30 p.m – 3:30 p.m

During the periods, Brain/MINDS DATA PORTAL・Marmoset Gene Atlas will not be available.

 

These schedules might vary depending on the situation.
Thank you for your understanding.
Brain/MINDS office

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Related Projects

  • International Brain Initiative
  • Marmoset Gene Atlas
  • Brain/MINDS Data Portal

Supported by

Japan Agency for Medical Research and Development