Brain Mapping by Integrated Neurotechnologies for Disease Studies

Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

Partner Projects

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An interactive deep learning-based approach reveals mitochondrial cristae topologies

The research group developed a novel deep learning (DL)-based image analysis platform called Python-based human-in-the-loop workflow (PHILOW). Analysis of dense, large, and isotropic volumes of electron microscopy using PHILOW reveals the complex 3D nanostructure of both inner and outer mitochondrial membranes and provides quantitative structural features of cristae in a large number of individual mitochondria.


Reward expectation influences on action-related activity of the nigrostriatal system

The research group uncovered the pivotal role the nigrostriatal system plays in integrating past rewards to dictate future actions in rats. This study provides insights into the influence of reward expectation on neuronal activity, challenging traditional beliefs about dopamine's role in action through the modulation of striatal output activity.


Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

Using MRI brain imaging data sets of four major psychiatric disorders from 14 institutions in a multicenter research system, we proposed a new data-driven classification based on subcortical regional volumes and found the association between this classification and cognitive/social functions. These results are expected to be useful for the development of new objective diagnostic methods for psychiatric disorders.


Nature Branded Contents: Focal Point on Brain Science in Japan

Focal Point on Brain Science in Japan, an advertisement feature collection showcasing research of Brain/MINDS and Brain/MINDS Beyond, was published on 3 August 2023 in the online version of Nature, a weekly international journal publishing the finest peer-reviewed research in science and technology.


Characteristics of auditory-related EEG responses in the early stages of schizophrenia

We found that auditory-evoked gamma oscillation decreased in ultra-high-risk individuals for psychosis and in patients with recent-onset schizophrenia, while spontaneous power of gamma oscillation remained unchanged. The results would be useful in understanding the mechanism of early stages of schizophrenia and contribute to future research on diagnosis and treatment. The work has been published in Translational Psychiatry.


The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: The second phase of the archive of digital records

In collaboration with Brain/MINDS Beyond and the Johns Hopkins of Medicine, the research group developed non-invasive high-resolution brain imaging for studying the neural circuits of various primate species. This valuable resource enhances our understanding of the human brain and neurological conditions through data-driven research. The findings have been published in Neuroimage as an invited article.


Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy

Epilepsy is a neurological disorder characterized by seizures due to excessive electrical activity in the brain. However, the precise mechanisms underlying the pathogenesis of epilepsy remain unknown. Using a novel radiotracer, [11C]K-2, the first technology to visualize and quantify α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in the living human brain, researchers have been able to offer insight into the role of AMPA receptor trafficking in epileptogenesis. Their findings could lead to the development of novel therapeutics for patients with epilepsy.


Past events

Related Projects

  • International Brain Initiative
  • Marmoset Gene Atlas
  • Brain/MINDS Data Portal

Supported by

Japan Agency for Medical Research and Development