Brain Mapping by Integrated Neurotechnologies for Disease Studies

Studying the neural networks controlling higher brain functions in the marmoset, to gain new insights into information processing and diseases of the human brain.

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2020.12.24

Optimization and Validation of Diffusion MRI-based Fiber Tracking with Neural Tracer Data as a Reference

The researchers utilized the diffusion MRI and neural tracer data of marmoset brains collected by the Brain/MINDS project to optimize the parameters of the algorithms for estimating whole-brain neural connections (connectome). The optimization allowed tracking of long-range fibers and raised an issue of parameter selection in connectomic studies.

2020.12.24

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons

Patients with 22q11.2 deletion syndrome (22q11.2DS) suffer from the onset risk for neuropsychiatric disorders over their lifetime. In this study, the researchers revealed “PRKR-Like Endoplasmic Reticulum Kinase-dependent vulnerabilities in dopaminergic neurons” as one of the molecular pathologies in brains of 22q11.2DS.

2020.09.17

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities

The researchers demonstrated that mimicking a de novo mutation of the schizophrenia-risk gene SETD1A in mice induced various abnormal behaviors relevant to schizophrenia. Setd1a in postsynaptic neurons positively regulates excitatory synaptic transmission and structure in the medial prefrontal cortex through histone modification and regulating the expression of diverse synaptic genes.

2020.09.04

Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment

Direct and indirect pathway medium-sized spiny neurons (dMSNs and iMSNs) in the neostriatum were selectively labeled with green and red fluorescent proteins by an AAV vector. Both pathways formed two axonal arborizations in the globus pallidus external segment, and dMSN axons converged in the center of iMSN projection fields.

2020.09.03

Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB

The researchers developed a simplified method for the production of AAV vectors, which drastically shortens the purification time from 1.5 days to 2 – 4 h. Systemic infusion of AAV-PHP.eB prepared using this method transduced whole brain. Transduction efficacy is comparable to the conventional method.

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Related Projects

  • International Brain Initiative
  • Marmoset Gene Atlas
  • Brain/MINDS Data Portal

Supported by

Japan Agency for Medical Research and Development