Generation and evaluation of a marmoset model of dementia

Research period : 2019-2023
Principal Investigator

Kazuhiko Seki

National Institute of Neuroscience, National Center of Neurology and Psychiatry

Translation from preclinical to clinical research remains a major challenge for the development of treatments for neurological disorders. To overcome this issue, disease models using non-human primates that have brain structures and functions similar to humans are attracting attention. In this research project, we aim to generate a marmoset model of Alzheimer's disease (AD) through the development of new reproductive engineering technology and to supply it to neuroscientists in Japan. In addition, we aim to develop biomarkers that can be common between humans and marmosets using AD model marmosets.

Co-Investigator

  • Eiko Minakawa

    National Institute of Neuroscience, National Center of Neurology and Psychiatry

  • Ikuo Tomioka

    Graduate School of Science and Technology, Shinshu University

  • Koichi Kato

    National Institute of Neuroscience, National Center of Neurology and Psychiatry

  • Yuko Saito

    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology

  • Toshihide Takeuchi

    Life Science Research Institute, Kindai University

  • Miho Shidahara

    Graduate School of Engineering, Tohoku University