Development of a method for linear modeling of brain-state and stimulus-related information

Research period : 2019-2023
Principal Investigator
近添 淳一

Junichi Chikazoe

National Institute for Physiological Science, National Institutes of Natural Sciences / Research Team, Araya Inc.

Recent studies have reported that non-invasive investigation of functional connectivity by resting state fMRI provides biomarkers for neuropsychiatric diseases. However, most available methods lack sufficient accuracy for diagnosis limiting traditional analysis methods. Here, we propose a method for quantitative estimation of neuronal network states, which dynamically change. Aiming at its clinical application, we hypothesize that spontaneous brain activity at rest reflects the computation of several parallel networks, which can be modeled by their linear combination.

Co-Investigator
  • Masakazu Agetsuma

    National Institute for Physiological Science, National Institutes of Natural Sciences