Research on high-speed super-resolution in vivo 3D imaging method by utilizing advanced laser light technology

Research period : 2019-2023
Principal Investigator
根本 知己

Tomomi Nemoto

Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences

The purpose of this subject is to realize biological super-resolution imaging that contributes to connectomics research. By taking full advantages of novel optical laser technologies, we will develop a system that can be applied for multiple fluorescence wavelengths and realize high-speed three-dimensional image acquisition. Finally, by utilizing stimulated emission suppression to break the spatial resolution limited by classical diffraction of light and by combining it with a multiphoton excitation microscope excellent for the deep observation of the living body, we will realize super-resolution imaging of a model animal's living brain.

Co-Investigator
  • Shunichi Sato

    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  • Hiroyuki Yokoyama

    New Industry Creation Hatchery Center, Tohoku University