Studies on neural circuit and molecular pathology based on human genome mutations in psychiatric disorders

Research period : 2019-2023
Principal Investigator
貝淵 弘三

Kozo Kaibuchi

Institute for Comprehensive Medical Science, Fujita Health University / Graduate School of Medicine, Nagoya University

We will combine behavior, morphology and dynamics of neural circuits, synaptic plasticity, and intracellular signaling analyses in psychiatric disorder model mice to elucidate the molecular and circuit pathology. Neurons and organoids derived from iPS cells established from patients with 22q11.2 deletion and tuberous sclerosis will also be characterized. The screening and verification of new mutation candidates involved in cross-disease episodes among schizophrenia, bipolar disorder, and autism spectrum disorder will be continued for additional elucidation of molecular and circuit pathology. The obtained information can be applied to the analysis of neural circuits and their functions in marmosets.

Co-Investigator
  • Norio Ozaki

    Graduate School of Medicine, Nagoya University
  • Yukihiro Noda

    Faculty of Pharmacy, Meijo University
  • Shinsuke Ishigaki

    Graduate School of Medicine, Nagoya University