Understanding the mechanism of Aβ-induced aggregated tau propagation and neurocircuit degeneration in Alzheimer's disease

Research period : 2019-2023
Principal Investigator
富田 泰輔

Taisuke Tomita

Graduate School of Pharmaceutical Sciences, The University of Tokyo

We will clarify the pathological relationship between amyloid-β (Aβ) deposition, the earliest pathological changes in Alzheimer disease (AD), and propagation of aggregated tau that causes the neurodegeneration. We will also elucidate the earliest damaged neurocircuit in the pathological process of AD using patient samples and disease models. Our research will highlight the key neuronal circuit that is damaged by Aβ-induced aggregated tau propagation and lead to an understanding of the conversion process from preclinical stage to AD.

Co-Investigator
  • Takeshi Ikeuchi

    Brain Research Institute, Niigata University
  • Tadafumi Hashimoto

    Graduate School of Medicine, The University of Tokyo
  • Kaoru Yamada

    Graduate School of Medicine, The University of Tokyo
  • Yukiko Hori

    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Sho Takatori

    Graduate School of Pharmaceutical Sciences, The University of Tokyo