Study for impairment of predictive function in psychiatric disorders using a bi-directional translational approach

Research period : 2019-2023
Principal Investigator
小池 進介

Shinsuke Koike

Graduate School of Arts and Sciences, The University of Tokyo

This research intends to conduct a cross-disease investigation for impairment of the predictive function in psychiatric disorders using a bi-directional translational approach (Patient – Human – Non-human primate – Mouse). We intend to find the translatable phenotypes for prefrontal cortex-dependent auditory predictive function and condition predictive function. We will expand the large-scale database of the multi-center magnetic resonance imaging study in Japan and measure for people with affective disorders and autism spectrum disorder. We will find the shared and disease-specific alterations of the phenotypes and the neural and molecular basis of the impairment of the predictive function in psychiatric disorders.

Co-Investigator
  • Toshiaki Onitsuka

    Graduate School of Medical Sciences, Kyushu University
  • Misako Komatsu

    RIKEN Center for Brain Science
  • Kenichiro Miura

    National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Kenji Tanaka

    School of Medicine, Keio University
  • Masatoshi Yoshida

    Center for Human Nature, Artificial Intelligence, and Neuroscience, Hokkaido University
  • Masanori Matsuzaki

    Graduate School of Medicine, The University of Tokyo
  • Takanori Uka

    Graduate Faculty of Interdisciplinary Research, University of Yamanashi
  • Sho Yagishita

    Graduate School of Medicine, The University of Tokyo
  • Maeri Yamamoto

    Nagoya University Hospital, Nagoya University
  • Kiyoto Kasai

    Graduate School of Medicine, The University of Tokyo
  • Naoto Kunii

    University Hospital, The University of Tokyo