Development of innovative method for an all-optical electrophysiology to measure and manipulate neural activity

Research period : 2017-2020
Principal Investigator
坂本 雅行

Masayuki Sakamoto

Graduate School of Biostudies, Kyoto University

We will develop an innovate method for “an all-optical electrophysiology” to record and manipulate the neural activity of multiple neurons simultaneously with cellular resolution in vivo. Firstly, we will generate novel opsin-based genetically encoded voltage indicators which show improved brightness and voltage sensitivity by two-photon excitation in vivo. Secondally, we will find new optogenetic tools that are available with new voltage indicator with cross-talk-free.

  • Yuki Sudo

    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University