Developing innovative therapeutic interventions for frontotemporal lobar degeneration based on the elucidation of neural circuit disruption


Gen Sobue

Graduate School of Medicine,
Nagoya University

In this project, we take charge of developing innovative therapeutic interventions for FTLD-ALS based on the elucidation of neuronal circuits break­down. Our mission is 1) to identify the specific early macro brain network disruption in FTLD/ALS patients; 2) to establish the translatable indicator leading to the clarification of ultra-early neuronal circuit involvement and subsequent progression by establishment of TDP-43/FUS mouse models; 3) to accelerate the development of novel diagnostic tool and treatment by validating the human and mouse findings using common marmoset models.