Generation of the 1st non-human primate model of Alzheimer’s disease
Takaomi C. Saido
We will work together with Hideyuki Okano Team (Keio & RIKEN) and Erika Sasaki Team (CIEA, RIKEN & Keio) to generate the 1st non-human primate model of Alzheimer’s disease (AD). Right now, experimental research of AD utilizes mouse models because they are easy to handle and to breed. The mouse models, however, differ from humans biologically, for instance, in the immune system and in cognition and thus may cause, at least in some cases, a failure in preclinical trials of medication candidates. So, non-human primate models could improve preclinical trials and may also contribute to elucidating the mechanism(s) underlying the transition of Aβ amyloidosis to tauopathy and neurodegeneration.