Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Development of innovative method for an all-optical electrophysiology to measure and manipulate neural activity.

Masayuki Sakamoto

Graduate School of Medicine,
The University of Tokyo

Yuki Sudo

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Okayama University

We will develop an innovate method for “an all-optical electrophysiology” to record and manipulate the neural activity of multiple neurons simultaneously with cellular resolution in vivo. Firstly, we will generate novel opsin-based genetically encoded voltage indicators which show improved brightness and voltage sensitivity by two-photon excitation in vivo. Secondally, we will find new optogenetic tools that are available with new voltage indicator with cross-talk-free.