Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Development of the marmoset embryo-manipulating technologies for efficient generation of knock-in animals and reduction of generation interval

Atsu Aiba

Graduate School of Medicine,
The University of Tokyo

Atsuo Ogura

Bioresource Engineering Division,
RIKEN BioResource Center

In order to accelerate brain mapping of the common marmoset, we are trying to develop three types of embryo-manipulating technology. Firstly, we are planning to develop technology for efficient generation of knock-in animals by manipulating embryos using genome editing techniques such as TALEN and CRISPR/Cas. Secondly, we are trying to develop embryo-freezing technology for efficient generation and for storage of genetically modified marmosets. Thirdly, we are trying to develop micro-insemination technology to reduce generation interval.