Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Development of innovative method for projection pathway specific gene expression to manipulate neural network

Akihiro Yamanaka

Research Institute of Environmental Medicine,
Nagoya University

Recent development of new techniques to control the activity of neurons, such as optogenetics or pharmacogenetics, enable study the function of neural network in vivo. However, these require expression of gene in the targeted neurons. In this research, we will develop new techniques to support functional mapping of marmoset brain by using newly developed high efficient retrograde and anterograde trans-synaptic Cre recombinase or flippase for neural pathway specific gene expression using multi-selection system. And we will develop teleopto for marmoset to manipulate specific neurons using optogenetics.