Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Developing cell type-specific gene expression techniques in marmoset brain

Hirokazu Hirai

Graduate School of Medicine,
Gunma University

Viral vectors carrying cell type-specific promoters allow us to express transgenes such as fluorescent proteins and/or functional molecules specifically in certain cell types in a temporally regulated manner. However, many cell type-specific promoters have relatively week promoter activity and large in size. Compact cell type-specific promoters having robust promoter activity are indispensable for viral vector-mediated selective labeling/functional alteration of a specific cell population or a specific neural circuit. In this project, we develop various cell type-specific promoters optimized in marmoset brain.