Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Translatable imaging and mechanistic controls of a pathological cascade in age-related neurodegenerative conditions

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Makoto Higuchi

Department of Functional Brain Imaging Research
National Institutes for Quantum and Radiological Science and Technology,
National Institute of Radiological Sciences

The current project is committed to development of imaging techniques applicable to neurodegenerative dementias and rodent and marmoset models of these diseases,in order to clarify the molecular basis of neural circuit abnormalities. We therefore aim to establish translatable indices of brain pathologies and dysfunctions by generating neuroimaging probes for pathological protein deposits and pathogenetic modifiers. Our research also focuses on chemogenetic reporters detectable by in-vivo imaging to delineate functional connectivity in the brain through imaging-guided manipulations of specific neural circuits