Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Molecular mechanisms of spreading of TDP-43 pathology

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Masato Hasegawa

Tokyo Metropolitan Institute of Medical Science,
Department of Dementia and Higher Brain Function

To investigate the molecular mechanisms of TDP-43 accumulation in cells,we will identify the regions and the sequences responsible for TDP-43 aggregation, and establish the cellular models of seeded aggregation of TDP- 43. Furthermore,we will inoculate these abnormal proteins (tau, alpha-synuclein and TDP-43,etc) into brains of mice and marmosets,and analyze the spreading of the abnormal lesions by immunohistochemistry.