Brain Mapping by Integrated Neurotechnologies for Disease Studies

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Identification of disease-common neural circuit abnormalities

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Tetsuo Kobayashi

Graduate School of Engineering,
Kyoto University

We develop an automated quantitative evaluation method of all nerve fiber bundles based on diffusion MRIs combined with a precise parcellation map of the whole brain. Subsequently,we apply the method to various neuropsychiatric disorders, such as schizophrenia and analyze disruption of white matter integrity in various disorders quantitatively. In addition, we investigate new high-speed MRI sequences and develop innovative neuroimaging techniques towards the goal to identify disease-specific and -common neural circuit abnormalities.